Figure 4
From: PTTG/securin activates expression of p53 and modulates its function
Activation of the p53 promoter by PTTG is mediated through the c-myc/max sequence. HEK293 (open bars) and PC3 (solid bars) were co-transfected with the pcDNA3.1-PTTG and p53/-172/-89 (wild-type myc/max binding sequence) or the p53/-172/-89-Δ-c-myc (mutated myc/max binding sequence) promoter construct. Transfections were performed in duplicate and the results are expressed as mean ± S.E.M of four independent experiments (*, p < 0.05 by Student's t-test).