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Figure 7 | Molecular Cancer

Figure 7

From: PTTG/securin activates expression of p53 and modulates its function

Figure 7

Overexpression of PTTG activates the expression of bax by upregulating p53 expression. A: MCF7 cells (open bars) and HEK293 cells (solid bars) were co-transfected with the bax promoter and increasing amounts of the pCDNA3.1-PTTG expression vector. Transfections were performed in duplicate and the results are expressed as the mean ± S.E.M of four independent experiments (*, p < 0.05 by Student's t-test). Results are represented as the fold increase compared to control. B: Western blot analysis of HEK293, MCF7 and PC3 cells transfected with PTTG for the expression of bax after 48 hours of transfection. β-Actin antibody was used as a control to assess any variation in protein concentration and loading.

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