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Figure 8 | Molecular Cancer

Figure 8

From: PTTG/securin activates expression of p53 and modulates its function

Figure 8

PTTG overexpression induces apoptosis. A: HEK293 cells were transfected with pcDNA 3.1 vector (1), PTTG cDNA (2), or p53 cDNA (3) for 48 hours before the TUNEL assay. B: Transfected HEK293 cells also were analyzed for apoptosis by flow cytometry. Plots show an accumulation of G1 cells upon transfection with PTTG and both an induction of sub-G1 and loss of G2 cells upon p53 transfection. Data are representative of two independent experiments, performed in triplicate.

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