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Figure 6 | Molecular Cancer

Figure 6

From: Mutation in mitochondrial complex I ND6 subunit is associated with defective response to hypoxia in human glioma cells

Figure 6

ND6 protein secondary structure. Predicted secondary structure for human ND6 protein. A, Hydropathy plot for the human ND6 protein. Red line: transmembrane helix preference; Blue line: beta-turn preference; Gray line: modified hydrophobic moment index; Dark red line: predicted transmembrane helix. B, The secondary structures predicted for the complete ND6 proteins. The models predict six hydrophobic domains (putative hydrophobic transmembrane helices) that are connected to each other by five loops (two external loops and three internal loops). The secondary structure of the normal protein is shown for reference; changes in secondary structure predicted to occur as a result of the mutation M14V in M010b cells; the M64V mutation in LHON and the A72V mutation in LHON are illustrated.

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Molecular Cancer

ISSN: 1476-4598