Figure 7

Homology-based modeling of ND6 proteins. Homology-based modeling of normal and mutated ND6 3D protein structures. By comparison to the predicted 3D structure of the normal ND6 protein, these models predict that the M14V mutation in M010b cells, the M64V mutation in LHON, and the A72V mutation in LHON would significantly disrupt the orientation of the entire ND6 protein within the mitochondrial membrane, and would alter the interactions of the individual helices of each protein.