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Table 2 List of the significantly up-regulated genes in the MPNSTs relative to the plexiform neurofibromas.

From: Molecular profiling of malignant peripheral nerve sheath tumors associated with neurofibromatosis type 1, based on large-scale real-time RT-PCR

GENES Gene definition Gene caracterisation Plexiform neurofibromas
(n = 14)
MPNSTs
(n = 9)
P1 ROC-AUC2
MKI67 Proliferation-related Ki-67 Antigen Cell proliferation 1.85 [0.14–5.85]3 33.2 [19.1–93.6] <0.01 1.000
BIRC5/Survivin Survivin Apoptosis 2.01 [0.13–10.6] 26.2 [9.39–715] <0.01 0.984
SPP1 Secreted phosphoprotein 1 (osteopontin) Growth factor 0.07 [0.00–6.78] 16.2 [6.11–58.5] <0.01 0.984
MMP13 Matrix metalloproteinase 13 Extracellular matrix
remodeling
0.18 [0.00–15.6] 119 [2.93–844] <0.01 0.968
TERT Telomere reverse transcriptase Senescence 0.00 [0.00–45.4] 53.7 [11.0–395] <0.01 0.960
MMP9 Matrix Metalloproteinase 9 (gelatinase B) Extracellular matrix
remodeling
0.56 [0.00–11.4] 38.0 [7.02–640] <0.01 0.960
TERC/hTR Telomerase RNA component Senescence 0.76 [0.22–4.32] 6.02 [2.60–29.4] <0.01 0.960
TOP2A Topoisomerase II alpha Cell proliferation 2.21 [0.27–24.5] 28.8 [10.1–294] <0.01 0.960
FOXM1 Forkhead box M1 Transcription factor 1.26 [0.30–11.1] 21.4 [4.59–119] <0.01 0.960
FOXA2/HNF3B Forkhead box A2 (hepatocyte
nuclear factor 3, beta)
Transcription factor 0.00 [0.00–2.13] 1.77 [0.09–49.2] <0.01 0.952
HMMR/RHAMM Hyaluronan receptor Signaling transduction 1.22 [0.06–6.40] 16.9 [6.31–54.8] <0.01 0.922
CXCL5 Chemokine (C-X-C motif) ligand 5 Growth factor 1.79 [0.00–52.1] 17.0 [5.18–2096] <0.01 0.913
OSF-2 Osteoblast specific factor 2
(fasciclin I-like, periostin)
Growth factor 3.25 [0.06–42.9] 30.5 [1.68–112] <0.01 0.873
CCNE2 Cyclin E2 Cell proliferation 2.29 [0.50–9.41] 11.3 [1.68–21.9] <0.01 0.873
EPHA7 Ephrin Receptor EPHA7 Growth factor receptor 2.35 [0.19–13.4] 11.3 [1.39–93.9] <0.01 0.865
TP73 Tumor protein p73 Apoptosis 0.89 [0.00–12.8] 15.9 [0.73–73.5] <0.01 0.833
  1. 1Mann and Whitney's U Test 2ROC (Receiver Operating Characteristics) – AUC (Area Under Curve) analysis 3Median [range] of gene mRNA levels