GENES | Gene definition | Gene caracterisation | Plexiform neurofibromas (n = 14) | MPNSTs (n = 9) | P1 | ROC-AUC2 |
---|---|---|---|---|---|---|
MKI67 | Proliferation-related Ki-67 Antigen | Cell proliferation | 1.85 [0.14–5.85]3 | 33.2 [19.1–93.6] | <0.01 | 1.000 |
BIRC5/Survivin | Survivin | Apoptosis | 2.01 [0.13–10.6] | 26.2 [9.39–715] | <0.01 | 0.984 |
SPP1 | Secreted phosphoprotein 1 (osteopontin) | Growth factor | 0.07 [0.00–6.78] | 16.2 [6.11–58.5] | <0.01 | 0.984 |
MMP13 | Matrix metalloproteinase 13 | Extracellular matrix remodeling | 0.18 [0.00–15.6] | 119 [2.93–844] | <0.01 | 0.968 |
TERT | Telomere reverse transcriptase | Senescence | 0.00 [0.00–45.4] | 53.7 [11.0–395] | <0.01 | 0.960 |
MMP9 | Matrix Metalloproteinase 9 (gelatinase B) | Extracellular matrix remodeling | 0.56 [0.00–11.4] | 38.0 [7.02–640] | <0.01 | 0.960 |
TERC/hTR | Telomerase RNA component | Senescence | 0.76 [0.22–4.32] | 6.02 [2.60–29.4] | <0.01 | 0.960 |
TOP2A | Topoisomerase II alpha | Cell proliferation | 2.21 [0.27–24.5] | 28.8 [10.1–294] | <0.01 | 0.960 |
FOXM1 | Forkhead box M1 | Transcription factor | 1.26 [0.30–11.1] | 21.4 [4.59–119] | <0.01 | 0.960 |
FOXA2/HNF3B | Forkhead box A2 (hepatocyte nuclear factor 3, beta) | Transcription factor | 0.00 [0.00–2.13] | 1.77 [0.09–49.2] | <0.01 | 0.952 |
HMMR/RHAMM | Hyaluronan receptor | Signaling transduction | 1.22 [0.06–6.40] | 16.9 [6.31–54.8] | <0.01 | 0.922 |
CXCL5 | Chemokine (C-X-C motif) ligand 5 | Growth factor | 1.79 [0.00–52.1] | 17.0 [5.18–2096] | <0.01 | 0.913 |
OSF-2 | Osteoblast specific factor 2 (fasciclin I-like, periostin) | Growth factor | 3.25 [0.06–42.9] | 30.5 [1.68–112] | <0.01 | 0.873 |
CCNE2 | Cyclin E2 | Cell proliferation | 2.29 [0.50–9.41] | 11.3 [1.68–21.9] | <0.01 | 0.873 |
EPHA7 | Ephrin Receptor EPHA7 | Growth factor receptor | 2.35 [0.19–13.4] | 11.3 [1.39–93.9] | <0.01 | 0.865 |
TP73 | Tumor protein p73 | Apoptosis | 0.89 [0.00–12.8] | 15.9 [0.73–73.5] | <0.01 | 0.833 |