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Table 2 List of the significantly up-regulated genes in the MPNSTs relative to the plexiform neurofibromas.

From: Molecular profiling of malignant peripheral nerve sheath tumors associated with neurofibromatosis type 1, based on large-scale real-time RT-PCR

GENES

Gene definition

Gene caracterisation

Plexiform neurofibromas

(n = 14)

MPNSTs

(n = 9)

P1

ROC-AUC2

MKI67

Proliferation-related Ki-67 Antigen

Cell proliferation

1.85 [0.14–5.85]3

33.2 [19.1–93.6]

<0.01

1.000

BIRC5/Survivin

Survivin

Apoptosis

2.01 [0.13–10.6]

26.2 [9.39–715]

<0.01

0.984

SPP1

Secreted phosphoprotein 1 (osteopontin)

Growth factor

0.07 [0.00–6.78]

16.2 [6.11–58.5]

<0.01

0.984

MMP13

Matrix metalloproteinase 13

Extracellular matrix

remodeling

0.18 [0.00–15.6]

119 [2.93–844]

<0.01

0.968

TERT

Telomere reverse transcriptase

Senescence

0.00 [0.00–45.4]

53.7 [11.0–395]

<0.01

0.960

MMP9

Matrix Metalloproteinase 9 (gelatinase B)

Extracellular matrix

remodeling

0.56 [0.00–11.4]

38.0 [7.02–640]

<0.01

0.960

TERC/hTR

Telomerase RNA component

Senescence

0.76 [0.22–4.32]

6.02 [2.60–29.4]

<0.01

0.960

TOP2A

Topoisomerase II alpha

Cell proliferation

2.21 [0.27–24.5]

28.8 [10.1–294]

<0.01

0.960

FOXM1

Forkhead box M1

Transcription factor

1.26 [0.30–11.1]

21.4 [4.59–119]

<0.01

0.960

FOXA2/HNF3B

Forkhead box A2 (hepatocyte

nuclear factor 3, beta)

Transcription factor

0.00 [0.00–2.13]

1.77 [0.09–49.2]

<0.01

0.952

HMMR/RHAMM

Hyaluronan receptor

Signaling transduction

1.22 [0.06–6.40]

16.9 [6.31–54.8]

<0.01

0.922

CXCL5

Chemokine (C-X-C motif) ligand 5

Growth factor

1.79 [0.00–52.1]

17.0 [5.18–2096]

<0.01

0.913

OSF-2

Osteoblast specific factor 2

(fasciclin I-like, periostin)

Growth factor

3.25 [0.06–42.9]

30.5 [1.68–112]

<0.01

0.873

CCNE2

Cyclin E2

Cell proliferation

2.29 [0.50–9.41]

11.3 [1.68–21.9]

<0.01

0.873

EPHA7

Ephrin Receptor EPHA7

Growth factor receptor

2.35 [0.19–13.4]

11.3 [1.39–93.9]

<0.01

0.865

TP73

Tumor protein p73

Apoptosis

0.89 [0.00–12.8]

15.9 [0.73–73.5]

<0.01

0.833

  1. 1Mann and Whitney's U Test 2ROC (Receiver Operating Characteristics) – AUC (Area Under Curve) analysis 3Median [range] of gene mRNA levels