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Table 2 Methylation frequencies among MSS and MSI colon cancer cell lines and primary colorectal tumors. Abbreviations; MSS, microsatellite stable; MSI, microsatellite instable; CRC, colorectal cancer; U, unmethylated;M, methylated. Note that the calculated methylation frequencies of the MSS cell lines includes results from three cell lines derived from the same patient.

From: A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines

  MSS MSI Total
Gene Cell lines CRCs Cell lines CRCs Cell lines CRCs
hMLH1 0/11 (0%) 0/25 (0%) 3/9 (33%) 11/28 (39%) 3/20 (15%) 11/53 (21%)
MGMT 5/11 (45%) 10/25 (40%) 5/9 (56%) 11/28 (39%) 10/20 (50%) 21/53 (40%)
p16 INK4a 8/11 (73%) 7/25 (28%) 7/9 (78%) 10/28 (36%) 15/20 (75%) 17/53 (32%)
p14 ARF 5/11 (45%) 3/24 (12%) 8/9 (89%) 17/28 (61%) 13/20 (65%) 20/52 (38%)
APC 2/11 (18%) 7/25 (28%) 2/9 (22%) 10/28 (36%) 4/20 (20%) 17/53 (32%)
E-cadherin 1/11 (9%) 10/24 (42%) 2/9 (22%) 11/28 (39%) 3/20 (15%) 21/52 (40%)