Table 2 Methylation frequencies among MSS and MSI colon cancer cell lines and primary colorectal tumors. Abbreviations; MSS, microsatellite stable; MSI, microsatellite instable; CRC, colorectal cancer; U, unmethylated;M, methylated. Note that the calculated methylation frequencies of the MSS cell lines includes results from three cell lines derived from the same patient.
From: A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines
| MSS | MSI | Total | ||||
|---|---|---|---|---|---|---|
| Gene | Cell lines | CRCs | Cell lines | CRCs | Cell lines | CRCs |
| hMLH1 | 0/11 (0%) | 0/25 (0%) | 3/9 (33%) | 11/28 (39%) | 3/20 (15%) | 11/53 (21%) |
| MGMT | 5/11 (45%) | 10/25 (40%) | 5/9 (56%) | 11/28 (39%) | 10/20 (50%) | 21/53 (40%) |
| p16 INK4a | 8/11 (73%) | 7/25 (28%) | 7/9 (78%) | 10/28 (36%) | 15/20 (75%) | 17/53 (32%) |
| p14 ARF | 5/11 (45%) | 3/24 (12%) | 8/9 (89%) | 17/28 (61%) | 13/20 (65%) | 20/52 (38%) |
| APC | 2/11 (18%) | 7/25 (28%) | 2/9 (22%) | 10/28 (36%) | 4/20 (20%) | 17/53 (32%) |
| E-cadherin | 1/11 (9%) | 10/24 (42%) | 2/9 (22%) | 11/28 (39%) | 3/20 (15%) | 21/52 (40%) |