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Table 3 CpG island methylation of selected genes compared with the patients clinicopathological features and tumor genetics. Abbreviations: Gen. Characteristics, Genetic Characteristics; MSI, microsatellite instability; MSS, microsatellite stable; NS, not significant; Clin. and Path. Features, Clinical and Pathological Features. Comparison of different groups were tested with Fisher exact test or Pearsons χ2 test, P values are two sided and are considered statistically significant when P ≤ 0.05. The table is based on primary tumors (53) and not patients (52) *Statistically significant Pearsons χ2 tests with expected count less than 5.

From: A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines

  hMLH1 MGMT p16 INK4a p14 ARF APC E-cadherin
  M   U M   U M   U M   U M   U M   U
Individuals                   
   No 11/53   42/53 21/53   32/53 17/53   36/53 20/52   32/52 17/53   36/53 21/52   31/52
Gen. Characteristics                   
Ploidy                   
   Diploid 10   20 10   20 10   20 18   12 11   19 13   17
   Aneuploid 1   22 11   12 7   16 2   20 6   17 8   14
   P value 0.02 NS NS < 0.001 NS NS
MSI-status                   
   MSI 11   17 11   17 10   18 17   11 10   18 11   17
   MSS 0   25 10   15 7   18 3   21 7   18 10   14
   P value < 0.001 NS NS 0.001 NS NS
TP53                   
   Wild type 11   22 12   21 11   22 16   16 8   25 13   19
   Mutation 0   16 7   9 5   11 4   12 7   9 7   9
   P value 0.01 NS NS NS NS NS
   wt+non G-A mutation 11   33 15   29 14   30 18   25 13   31 17   26
   G-A mutation 0   4 3   1 1   3 1   3 1   3 2   2
   P value NS NS NS NS NS NS
K-Ras                   
   Wild type 8   19 13   14 9   18 12   15 7   20 9   18
   Mutation 1   14 6   9 3   12 2   12 6   9 6   8
   P value NS NS NS 0.08 NS NS
   wt+non G-A mutation 8   23 15   16 9   22 13   18 8   23 10   21
   G-A mutation 1   10 4   7 3   8 1   9 5   6 5   5
   P value NS NS NS NS NS NS
APC                   
   Wild type 7   19 12   14 10   16 9   17 9   17 12   14
   Mutation 3   23 8   18 7   19 10   15 8   18 9   16
   P value NS NS NS NS NS NS
Clin. and Path. Features                   
Sex                   
   Male 2   23 9   16 8   17 6   19 10   15 8   17
   Female 9   19 12   16 9   19 14   13 7   21 13   14
   P value 0.04 NS NS 0.05 NS NS
Age (years)                   
   <68 2   21 10   13 4   19 7   16 8   15 9   14
   ≥68 9   21 11   19 13   17 13   16 9   21 12   17
   P value 0.09 NS 0.07 NS NS NS
Location                   
   Right 10   8 7   11 7   11 12   6 7   11 7   11
   Left 1   19 8   12 9   11 5   14 6   14 8   11
   Rectum 0   14 6   8 1   13 2   12 4   10 5   9
   P value < 0.001* NS 0.05 0.01 NS NS
Histologic grade                   
   Poorly differentiated 4   8 7   5 6   6 7   4 5   7 4   7
   Moderately differentiated 7   30 13   24 11   26 12   25 11   26 14   23
   Well differentiated 0   3 1   2 0   3 0   3 1   2 2   1
   P value NS NS NS NS NS NS
Dukes' classification                   
   A 2   2 3   1 1   3 2   2 0   4 1   3
   B 5   22 10   17 8   19 9   17 13   14 12   14
   C 2   13 4   11 4   11 4   11 3   12 5   10
   D 2   5 4   3 4   3 5   2 1   6 3   4
   P value NS NS NS NS 0.07 NS
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Molecular Cancer

ISSN: 1476-4598