From: A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines
 | hMLH1 | MGMT | p16 INK4a | p14 ARF | APC | E-cadherin | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | M |  | U | M |  | U | M |  | U | M |  | U | M |  | U | M |  | U |
Individuals | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   No | 11/53 |  | 42/53 | 21/53 |  | 32/53 | 17/53 |  | 36/53 | 20/52 |  | 32/52 | 17/53 |  | 36/53 | 21/52 |  | 31/52 |
Gen. Characteristics | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Ploidy | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Diploid | 10 |  | 20 | 10 |  | 20 | 10 |  | 20 | 18 |  | 12 | 11 |  | 19 | 13 |  | 17 |
   Aneuploid | 1 |  | 22 | 11 |  | 12 | 7 |  | 16 | 2 |  | 20 | 6 |  | 17 | 8 |  | 14 |
   P value | 0.02 | NS | NS | < 0.001 | NS | NS | ||||||||||||
MSI-status | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   MSI | 11 |  | 17 | 11 |  | 17 | 10 |  | 18 | 17 |  | 11 | 10 |  | 18 | 11 |  | 17 |
   MSS | 0 |  | 25 | 10 |  | 15 | 7 |  | 18 | 3 |  | 21 | 7 |  | 18 | 10 |  | 14 |
   P value | < 0.001 | NS | NS | 0.001 | NS | NS | ||||||||||||
TP53 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Wild type | 11 |  | 22 | 12 |  | 21 | 11 |  | 22 | 16 |  | 16 | 8 |  | 25 | 13 |  | 19 |
   Mutation | 0 |  | 16 | 7 |  | 9 | 5 |  | 11 | 4 |  | 12 | 7 |  | 9 | 7 |  | 9 |
   P value | 0.01 | NS | NS | NS | NS | NS | ||||||||||||
   wt+non G-A mutation | 11 |  | 33 | 15 |  | 29 | 14 |  | 30 | 18 |  | 25 | 13 |  | 31 | 17 |  | 26 |
   G-A mutation | 0 |  | 4 | 3 |  | 1 | 1 |  | 3 | 1 |  | 3 | 1 |  | 3 | 2 |  | 2 |
   P value | NS | NS | NS | NS | NS | NS | ||||||||||||
K-Ras | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Wild type | 8 |  | 19 | 13 |  | 14 | 9 |  | 18 | 12 |  | 15 | 7 |  | 20 | 9 |  | 18 |
   Mutation | 1 |  | 14 | 6 |  | 9 | 3 |  | 12 | 2 |  | 12 | 6 |  | 9 | 6 |  | 8 |
   P value | NS | NS | NS | 0.08 | NS | NS | ||||||||||||
   wt+non G-A mutation | 8 |  | 23 | 15 |  | 16 | 9 |  | 22 | 13 |  | 18 | 8 |  | 23 | 10 |  | 21 |
   G-A mutation | 1 |  | 10 | 4 |  | 7 | 3 |  | 8 | 1 |  | 9 | 5 |  | 6 | 5 |  | 5 |
   P value | NS | NS | NS | NS | NS | NS | ||||||||||||
APC | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Wild type | 7 |  | 19 | 12 |  | 14 | 10 |  | 16 | 9 |  | 17 | 9 |  | 17 | 12 |  | 14 |
   Mutation | 3 |  | 23 | 8 |  | 18 | 7 |  | 19 | 10 |  | 15 | 8 |  | 18 | 9 |  | 16 |
   P value | NS | NS | NS | NS | NS | NS | ||||||||||||
Clin. and Path. Features | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Sex | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Male | 2 |  | 23 | 9 |  | 16 | 8 |  | 17 | 6 |  | 19 | 10 |  | 15 | 8 |  | 17 |
   Female | 9 |  | 19 | 12 |  | 16 | 9 |  | 19 | 14 |  | 13 | 7 |  | 21 | 13 |  | 14 |
   P value | 0.04 | NS | NS | 0.05 | NS | NS | ||||||||||||
Age (years) | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   <68 | 2 |  | 21 | 10 |  | 13 | 4 |  | 19 | 7 |  | 16 | 8 |  | 15 | 9 |  | 14 |
   ≥68 | 9 |  | 21 | 11 |  | 19 | 13 |  | 17 | 13 |  | 16 | 9 |  | 21 | 12 |  | 17 |
   P value | 0.09 | NS | 0.07 | NS | NS | NS | ||||||||||||
Location | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Right | 10 |  | 8 | 7 |  | 11 | 7 |  | 11 | 12 |  | 6 | 7 |  | 11 | 7 |  | 11 |
   Left | 1 |  | 19 | 8 |  | 12 | 9 |  | 11 | 5 |  | 14 | 6 |  | 14 | 8 |  | 11 |
   Rectum | 0 |  | 14 | 6 |  | 8 | 1 |  | 13 | 2 |  | 12 | 4 |  | 10 | 5 |  | 9 |
   P value | < 0.001* | NS | 0.05 | 0.01 | NS | NS | ||||||||||||
Histologic grade | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Poorly differentiated | 4 |  | 8 | 7 |  | 5 | 6 |  | 6 | 7 |  | 4 | 5 |  | 7 | 4 |  | 7 |
   Moderately differentiated | 7 |  | 30 | 13 |  | 24 | 11 |  | 26 | 12 |  | 25 | 11 |  | 26 | 14 |  | 23 |
   Well differentiated | 0 |  | 3 | 1 |  | 2 | 0 |  | 3 | 0 |  | 3 | 1 |  | 2 | 2 |  | 1 |
   P value | NS | NS | NS | NS | NS | NS | ||||||||||||
Dukes' classification | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   A | 2 |  | 2 | 3 |  | 1 | 1 |  | 3 | 2 |  | 2 | 0 |  | 4 | 1 |  | 3 |
   B | 5 |  | 22 | 10 |  | 17 | 8 |  | 19 | 9 |  | 17 | 13 |  | 14 | 12 |  | 14 |
   C | 2 |  | 13 | 4 |  | 11 | 4 |  | 11 | 4 |  | 11 | 3 |  | 12 | 5 |  | 10 |
   D | 2 |  | 5 | 4 |  | 3 | 4 |  | 3 | 5 |  | 2 | 1 |  | 6 | 3 |  | 4 |
   P value | NS | NS | NS | NS | 0.07 | NS |