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Table 3 CpG island methylation of selected genes compared with the patients clinicopathological features and tumor genetics. Abbreviations: Gen. Characteristics, Genetic Characteristics; MSI, microsatellite instability; MSS, microsatellite stable; NS, not significant; Clin. and Path. Features, Clinical and Pathological Features. Comparison of different groups were tested with Fisher exact test or Pearsons χ2 test, P values are two sided and are considered statistically significant when P ≤ 0.05. The table is based on primary tumors (53) and not patients (52) *Statistically significant Pearsons χ2 tests with expected count less than 5.

From: A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines

 

hMLH1

MGMT

p16 INK4a

p14 ARF

APC

E-cadherin

 

M

 

U

M

 

U

M

 

U

M

 

U

M

 

U

M

 

U

Individuals

                  

   No

11/53

 

42/53

21/53

 

32/53

17/53

 

36/53

20/52

 

32/52

17/53

 

36/53

21/52

 

31/52

Gen. Characteristics

                  

Ploidy

                  

   Diploid

10

 

20

10

 

20

10

 

20

18

 

12

11

 

19

13

 

17

   Aneuploid

1

 

22

11

 

12

7

 

16

2

 

20

6

 

17

8

 

14

   P value

0.02

NS

NS

< 0.001

NS

NS

MSI-status

                  

   MSI

11

 

17

11

 

17

10

 

18

17

 

11

10

 

18

11

 

17

   MSS

0

 

25

10

 

15

7

 

18

3

 

21

7

 

18

10

 

14

   P value

< 0.001

NS

NS

0.001

NS

NS

TP53

                  

   Wild type

11

 

22

12

 

21

11

 

22

16

 

16

8

 

25

13

 

19

   Mutation

0

 

16

7

 

9

5

 

11

4

 

12

7

 

9

7

 

9

   P value

0.01

NS

NS

NS

NS

NS

   wt+non G-A mutation

11

 

33

15

 

29

14

 

30

18

 

25

13

 

31

17

 

26

   G-A mutation

0

 

4

3

 

1

1

 

3

1

 

3

1

 

3

2

 

2

   P value

NS

NS

NS

NS

NS

NS

K-Ras

                  

   Wild type

8

 

19

13

 

14

9

 

18

12

 

15

7

 

20

9

 

18

   Mutation

1

 

14

6

 

9

3

 

12

2

 

12

6

 

9

6

 

8

   P value

NS

NS

NS

0.08

NS

NS

   wt+non G-A mutation

8

 

23

15

 

16

9

 

22

13

 

18

8

 

23

10

 

21

   G-A mutation

1

 

10

4

 

7

3

 

8

1

 

9

5

 

6

5

 

5

   P value

NS

NS

NS

NS

NS

NS

APC

                  

   Wild type

7

 

19

12

 

14

10

 

16

9

 

17

9

 

17

12

 

14

   Mutation

3

 

23

8

 

18

7

 

19

10

 

15

8

 

18

9

 

16

   P value

NS

NS

NS

NS

NS

NS

Clin. and Path. Features

                  

Sex

                  

   Male

2

 

23

9

 

16

8

 

17

6

 

19

10

 

15

8

 

17

   Female

9

 

19

12

 

16

9

 

19

14

 

13

7

 

21

13

 

14

   P value

0.04

NS

NS

0.05

NS

NS

Age (years)

                  

   <68

2

 

21

10

 

13

4

 

19

7

 

16

8

 

15

9

 

14

   ≥68

9

 

21

11

 

19

13

 

17

13

 

16

9

 

21

12

 

17

   P value

0.09

NS

0.07

NS

NS

NS

Location

                  

   Right

10

 

8

7

 

11

7

 

11

12

 

6

7

 

11

7

 

11

   Left

1

 

19

8

 

12

9

 

11

5

 

14

6

 

14

8

 

11

   Rectum

0

 

14

6

 

8

1

 

13

2

 

12

4

 

10

5

 

9

   P value

< 0.001*

NS

0.05

0.01

NS

NS

Histologic grade

                  

   Poorly differentiated

4

 

8

7

 

5

6

 

6

7

 

4

5

 

7

4

 

7

   Moderately differentiated

7

 

30

13

 

24

11

 

26

12

 

25

11

 

26

14

 

23

   Well differentiated

0

 

3

1

 

2

0

 

3

0

 

3

1

 

2

2

 

1

   P value

NS

NS

NS

NS

NS

NS

Dukes' classification

                  

   A

2

 

2

3

 

1

1

 

3

2

 

2

0

 

4

1

 

3

   B

5

 

22

10

 

17

8

 

19

9

 

17

13

 

14

12

 

14

   C

2

 

13

4

 

11

4

 

11

4

 

11

3

 

12

5

 

10

   D

2

 

5

4

 

3

4

 

3

5

 

2

1

 

6

3

 

4

   P value

NS

NS

NS

NS

0.07

NS