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Figure 2 | Molecular Cancer

Figure 2

From: CpG methylation of the FHIT, FANCF, cyclin-D2, BRCA2 and RUNX3 genes in Granulosa cell tumors (GCTs) of ovarian origin

Figure 2

(a) Representative examples of MSP of FHIT, FANCF, Cyclin-D2 and BRCA2 genes in cell lines and tumor samples; -ve, negative control (water blank PCR mixture without template); +ve, positive control (normal lymphocyte DNA treated with Sss I methyl transferase). The unmethylated form of p16 was amplified as a control to check DNA integrity. (b) Representative examples of MSP with RUNX3 gene and its expression before and after treatment with 5'-AZA-dC in different ovarian tissue (both normal and cancerous) using RT-PCR. UT: untreated; T: treated with 5'-AZA-dC; T2–T25: tumour samples.

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Molecular Cancer

ISSN: 1476-4598