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Table 2 Association of grade classification (IA, IB and IC) and promoter methylation of different genes in granulosa cell tumours of ovarian origin

From: CpG methylation of the FHIT, FANCF, cyclin-D2, BRCA2 and RUNX3 genes in Granulosa cell tumors (GCTs) of ovarian origin

Genes Methylation Status Grade classification p-value* p-value p-value** p-value p-value#
   IA IB IC      
FHIT Methylated 3 1 3 1 0.0526 0.5856 0.2352 0.041#
  Unmethylated 8 9 1      
FANCF Methylated 2 1 3 0.6609 0.0312 1 0.0769 0.041#
  Unmethylated 9 9 1      
Cyclin-D2 Methylated 0 0 3 0.23 0.0017 - 0.0088 0.011#
  Unmethylated 11 10 1      
BRCA2 Methylated 0 0 1 1 0.16 - 0.2667 0.2857
  Unmethylated 11 10 3      
RUNX3 Methylated 7 3 4 0.6887 0.1052 0.1984 0.5165 0.0699
  Unmethylated 4 7 0      
  1. *Fisher's exact test. IA type vs. IB and IC type; †Fisher's exact test. IA and IB type vs. IC type GCTs of ovarian origin;
  2. **Fisher's exact test. IA type vs. IB; ‡Fisher's exact test. IA type vs. IC type; #Fisher's exact test. IB type vs. IC type GCTs of ovarian origin