CpG methylation of the FHIT, FANCF, cyclin-D2, BRCA2 and RUNX3 genes in Granulosa cell tumors (GCTs) of ovarian origin

Table 2 Association of grade classification (IA, IB and IC) and promoter methylation of different genes in granulosa cell tumours of ovarian origin

Genes	Methylation Status	Grade classification			p-value*	p-value^†	p-value**	p-value^‡	p-value^#
		IA	IB	IC
FHIT	Methylated	3	1	3	1	0.0526	0.5856	0.2352	0.041^#
	Unmethylated	8	9	1
FANCF	Methylated	2	1	3	0.6609	0.0312^†	1	0.0769	0.041^#
	Unmethylated	9	9	1
Cyclin-D2	Methylated	0	0	3	0.23	0.0017^†	-	0.0088^‡	0.011^#
	Unmethylated	11	10	1
BRCA2	Methylated	0	0	1	1	0.16	-	0.2667	0.2857
	Unmethylated	11	10	3
RUNX3	Methylated	7	3	4	0.6887	0.1052	0.1984	0.5165	0.0699
	Unmethylated	4	7	0

*Fisher's exact test. IA type vs. IB and IC type; †Fisher's exact test. IA and IB type vs. IC type GCTs of ovarian origin;
**Fisher's exact test. IA type vs. IB; ‡Fisher's exact test. IA type vs. IC type; #Fisher's exact test. IB type vs. IC type GCTs of ovarian origin

ISSN: 1476-4598