Skip to main content

Table 5 Relationships between the prognostic (+/- relapses) and the mRNA levels of BRCA2, DNMT3B and CCNE1 in 104 ERα-positive postmenopausal breast tumors

From: Identification of a three-gene expression signature of poor-prognosis breast carcinoma

GENES Tumors without relapses (n = 73) Tumors with relapses (n = 31) P a ROC-AUCb
BRCA2 4.7 (1.0–23.6c 7.5 (1.4–38.4) 0.0018 0.694 (0.58–0.80)d
DNMT3B 3.6 (1.0–27.8) 6.2 (2.3–74.1) 0.00052 0.716 (0.61–0.82)
CCNE1 6.4 (1.0–46.2) 9.0 (1.3–62.8) 0.028 0.636 (0.51–0.76)
  1. a:P value, Mann-Whitney U test.
  2. b:ROC (Receiver Operating Characteristics) – AUC (Area Under Curve) analysis
  3. c:Median (range) of gene mRNA levels
  4. d:AUC value (95% confidence interval)