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Figure 4 | Molecular Cancer

Figure 4

From: The proteosome inhibitor MG132 attenuates Retinoic Acid Receptor trans-activation and enhances trans-repression of Nuclear Factor κB. Potential relevance to chemo-preventive interventions with retinoids

Figure 4

RAR reciprocally regulates anti-metastatic TIMP 1 and pro-metastatic MMP 9 in a ligand dependent and reversible manner. MMP 9 and TIMP 1 gene expression in WT-Line 1 tumor cells exposed to at-RA +/- AGN193109 for 24 hours at the indicated concentrations was assessed by real time PCR. The results represent the average of 3 independent experiments, normalized to β-actin loading controls.

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