Figure 8
From: Genetic alteration and gene expression modulation during cancer progression
Progression model of prostate cancer. The prostate cancer progression model suggests that normal prostatic epithelium changes to prostatic intraepithelial neoplasm (PIN), which in turn becomes localized invasive cancer, metastatic, and, finally, hormone refractory disease with increasing severity reflected in a higher Gleason grade. This figure outlines the changes that occur in the progression of prostate cancer.