Table 2 Down-regulated genes in rats fed with WPH diet*

Cell adhesion

   Embigin

AJ009698

-6.57

0

   Cadherin 17

L46874

-4.8

0.036

   Cadherin

X78997

-3.36

0.004

   Protein tyrosine phosphatase

M60103

-2.64

0.004

   Cytokeratin-8

S76054

-2.71

0

   Trans-Golgi network integral membrane protein TGN38

X53565

-4.92

0.012

   Tumor-associated calcium signal transducer 1

AJ001044

-9.37

0.001

   Claudin-3

AJ011656

-7.55

0.02

   Claudin-9

AJ011811

-5.12

0

Cell cycle/growth control

   Mapk6

M64301

-2.61

0.003

   Epithelial membrane protein 1

Z54212

-4.67

0.015

   Glucagon

K02813

-7.73

0.005

   Peptide tyrosine-tyrosine (YY)

M17523

-4.56

0.001

   Src related tyrosine kinase

U09583

-3.31

0.033

   FGF receptor activating protein

U57715

-4.25

0.002

   Cyclin D1

D14014

-1.97

0.001

   Neu oncogene

X03362

-2.61

0.017

Defense/immunity protein

   Seminal vesicle secretion protein iv

J00791

-5.35

0.001

   Putative cell surface antigen

U89744

-5.22

0.008

   Decay accelerating factor GPI

AF039583

-6.12

0

   Beta defensin-1

AF093536

-26.78

0.001

Detoxification/antioxidation

   Glutathione S-transferase

J02810

-5.17

0

   Glutathione S-transferase Yb

X04229

-9.33

0

J03914

-2.43

0.002

   Glutathione S-transferase, alpha 1

K01932

-3.07

0.002

   Glutathione transferase, subunit 8

X62660

-6.42

0.001

   Glutathione S-transferase Yc1

S72505

-3.69

0.004

   Glutathione S-transferase Yc2

S72506

-21.38

0.008

   N-acetyltransferase 1

U01348

-4.64

0.003

   Cytochrome P450CMF1b

J02869

-8.23

0.001

   Cytochrome P450 4F4

U39206

-6.43

0.004

   Cytochrome P450 monooxygenase

U39943

-2.82

0.011

   Cytochrome P450 pseudogene

U40004

-2.87

0

   Cytochrome P450 3A9

U46118

-6.91

0

   Cytochrome P450IVF

M94548

-5.78

0.002

   Cytochrome P450, subfamily 51

U17697

-2.07

0.005

   Alcohol dehydrogenase

M15327

-2.06

0.025

   Aldehyde dehydrogenase

M23995

-10.56

0.035

AF001898

-2.72

0.004

   D-amino-acid oxidase

AB003400

-13.69

0

   3-methylcholanthrene-inducible UDP-glucuronosyltransferase

S56937

-9

0

   UDP-glucuronosyltransferase

D38062

-3.17

0.005

D38065

-3.29

0.002

   UDP glycosyltransferase 1

D83796

-6.87

0

J02612

-6.58

0

J05132

-4.03

0

Metabolism

   Meprin 1 alpha

S43408

-3.82

0.014

   Brain serine protease bsp1

AJ005641

-4.42

0.007

   Cystathionine gamma-lyase

D17370

-3.05

0.002

   Cathepsin S

L03201

-2.62

0

   Meprin beta-subunit

M88601

-5

0.004

   Disintegrin and metalloprotease domain 7

X66140

-11.91

0

   Fucosyltransferase 1

AB006137

-4.96

0.001

   Fucosyltransferase 2

AB006138

-7.97

0.017

   UDP-glucose:ceramide glycosyltransferase

AF047707

-2.86

0.007

   Type II Hexokinase

D26393

-2.7

0.001

   Hexokinase II

S56464

-4.45

0.007

   CDP-diacylglycerol synthase

AB009999

-4.66

0

   Carboxylesterase precursor

AB010635

-5.29

0.002

   Fatty acid Coenzyme A ligase

AB012933

-2.5

0.041

   3beta-HSD

L17138

-3.27

0

   11-beta-hydroxylsteroid dehydrogenase type 2

U22424

-3

0.001

   Peroxiredoxin 6

AF014009

-3.55

0.01

   Platelet phospholipase A2

X51529

-3.25

0.001

Ligand binding/carrier

   Carnitine transporter

AB017260

-3.95

0.005

   Chloride channel (ClC-2)

AF005720

-5.69

0.002

   Putative potassium channel

AF022819

-4.84

0

   Mitochondrial dicarboxylate carrier

AJ223355

-3.55

0.009

   Aquaporin 3

D17695

-7.83

0

   Na_H_Exchanger

L11236

-9.81

0.003

   Angiotensin/vasopressin receptor (AII/AVP)

M85183

-3.3

0.002

   H+, K+-ATPase

M90398

-13.87

0

   Intestinal fatty acid binding protein

K01180

-7.29

0.001

   Apolipoprotein A-I precursor

M00001

-3.45

0.023

   Apolipoprotein A-I

J02597

-2.47

0.003

   Sodium-hydrogen exchange protein-isoform 3

M85300

-7.36

0.004

   Liver fatty acid binding protein

V01235

-2.62

0

   Sodium transporter

X59677

-3.8

0

   Cation transporter

X78855

-3.62

0.003

   ATP-binding cassette

AB010467

-3.89

0.004

   Methionine adenosyltransferase II, alpha

J05571

-2.91

0.007

   Phenylalanine hydroxylase

M12337

-7.43

0

   Carbonic anhydrase IV

S68245

-4.28

0.011

Signal transduction

   B7 antigen

X76697

-170.95

0.002

   CD24 antigen

U49062

-3.08

0

   Chemokine CX3C

AF030358

-5.04

0.011

   Itmap1

AF022147

-7.5

0.001

   HCNP

E05646

-2.5

0.001

   Brain glucose-transporter protein

M13979

-2.97

0.019

   Protein kinase C delta

M18330

-2.48

0.002

   Guanylate cyclase 2C

M55636

-4.58

0.003

   A2b-adenosine receptor

M91466

-2.8

0.04

   Guanylate cyclase activator 2A

M95493

-4.18

0.005

   Phospholipase C beta-3

M99567

-2.57

0.018

   Tm4sf3

Y13275

-3.33

0

   Phospholipase D

AB000778

-2.71

0.009

   BEM-2

D45413

-6.41

0.015

   Sgk

L01624

-3.93

0

Stress response/apoptosis

   Prostaglandin D synthetase

J04488

-43.11

0.009

   GTP cyclohydrolase I

M58364

-3.26

0.014

Structure proteins

   Chromogranin B (Chgb)

AF019974

-2.56

0.005

   Intestinal mucin

M76740

-5.09

0.002

   Muc3

U76551

-11.07

0.006

   Mucin-like protein

M81920

-11.97

0.001

   Myosin 5B

U60416

-3.94

0

   Keratin 18

X81448

-3.23

0.004

   Keratin 19

X81449

-2.69

0.001

   ZG-16p protein

Z30584

-4.43

0.002

   Plasmolipin

Z49858

-7.2

0

   Cytokeratin 21

M63665

-4.96

0

   Syndecan

S61865

-3.3

0.006

   Claudin 3

M74067

-6.68

0.01

Transcription factor/regulator

   Hepatocyte nuclear factor 3 gamma

AB017044

-6.96

0

   Apolipoprotein B mRNA editing protein

L07114

-2.34

0

   DNA-binding inhibitor

L23148

-4.1

0.01

   Kruppel-like factor 4 (gut)

L26292

-3.08

0.017

Others

   Prolactin receptor

M74152

-3.26

0.014

   LOC286964

U89280

-2.96

0.003

   Ckmt1

X59737mRNA

-2.65

0.025

   Arginase II

U90887

-23.69

0

   Deleted in malignant brain tumors 1

U32681

-3.47

0.002

   3' end GAA-triplet repeat

L13025

-2.73

0.001

   Polymeric immunoglobulin receptor

L13235

-2.93

0.004