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Table 3 Up-regulated genes in rats fed with WPH diet*

From: Dietary exposure to soy or whey proteins alters colonic global gene expression profiles during rat colon tumorigenesis

Category and Gene Name

Probe Set GB Accession No.

Fold Change

P value

Cell adhesion

   

   Fibronectin

X05834

2.3

0

   EGF-containing fibulin-like extracellular matrix protein 1

D89730

2.17

0.004

Cell cycle/growth control

   

   Somatostatin

M25890

2.72

0.001

   Somatostatin-14

K02248

3.87

0.009

   APEG-1

U57097

3.24

0.002

Defense/immunity protein

   

   IgG gamma heavy chain

M28670

2.21

0.009

   T-cell receptor beta chain

X14319

2.14

0

   Adipsin

M92059

3.21

0

Ligand binding/carrier

   

   Angiotensin receptor

M86912

2.75

0.017

   Calretinin

X66974

2.52

0.005

   Purkinje cell protein 4

M24852

3.06

0.001

   Secretogranin III

U02983

2.77

0.005

   Secretogranin II

M93669

2.84

0.001

   Aquaporin 1

X67948

3.4

0.008

   Cacna2d1

M86621

2.84

0

   Retinol-binding protein

M10934

2.17

0.018

Metabolism

   

   Lipoprotein lipase

L03294

2.72

0

   Ubiquitin carboxyl-terminal hydrolase

D10699

3

0.003

Signal transduction

   

   Thy-1 protein

X02002

2.89

0.002

   CD3 gamma-chain

S79711

3.28

0.002

   Synapsin

M27925

3.94

0.001

   Alpha-actinin-2 associated LIM protein

AF002281

2.74

0.009

   RESP18

L25633

2.74

0.033

   T3 delta protein

X53430

2.75

0.003

   Protein phosphatase inhibitor-1

J05592t

2.6

0.009

   CART protein

U10071

2.16

0.001

   Neuroendrocrine protein

M63901

3.7

0.006

   Protein kinase C-binding protein Zeta1

U63740

3.14

0.003

   cannabinoid receptor 1

X55812

2.17

0.002

   Guanylyl cyclase A

J05677

3.18

0.007

   Tachykinin 1

X56306

2.36

0.036

   Protein tyrosine phosphatase

L19180

2.47

0.041

   Argininosuccinate synthetase

X12459

4.69

0.004

Stress response/apoptosis

   

   Small inducible cytokine

Y08358

3.35

0.029

Structure proteins

   

   Fast myosin alkali light chain

L00088

4.52

0.03

   Light molecular-weight neurofilament

AF031880

2.41

0

   Neurofilament protein middle

Z12152

2.97

0.006

   Alpha-tubulin

V01227

2.25

0

   Peripherin

AF031878

2.82

0.007

Transcription factor/regulator

   

   snRNP

M29293

2.11

0.004

   snRNP-associated polypeptide

X73411

3.33

0.002

Others

   

   C1-13 gene product

X52817

3.17

0

   ND5, ND6

S46798

2.31

0.015

   Sensory neuron synuclein

X86789

2.84

0

  1. *Changes in gene expression were determined by t-test (DMT), comparative analysis (MAS 5.0), and SAM (Stanford). Gene expression profiles from CAS animals were used as control. P value and fold change are based on the DMT analysis; whereas listed genes met all of the analytical criteria as described in Methods.
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Molecular Cancer

ISSN: 1476-4598