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Table 3 Up-regulated genes in rats fed with WPH diet*

From: Dietary exposure to soy or whey proteins alters colonic global gene expression profiles during rat colon tumorigenesis

Category and Gene Name Probe Set GB Accession No. Fold Change P value
Cell adhesion    
   Fibronectin X05834 2.3 0
   EGF-containing fibulin-like extracellular matrix protein 1 D89730 2.17 0.004
Cell cycle/growth control    
   Somatostatin M25890 2.72 0.001
   Somatostatin-14 K02248 3.87 0.009
   APEG-1 U57097 3.24 0.002
Defense/immunity protein    
   IgG gamma heavy chain M28670 2.21 0.009
   T-cell receptor beta chain X14319 2.14 0
   Adipsin M92059 3.21 0
Ligand binding/carrier    
   Angiotensin receptor M86912 2.75 0.017
   Calretinin X66974 2.52 0.005
   Purkinje cell protein 4 M24852 3.06 0.001
   Secretogranin III U02983 2.77 0.005
   Secretogranin II M93669 2.84 0.001
   Aquaporin 1 X67948 3.4 0.008
   Cacna2d1 M86621 2.84 0
   Retinol-binding protein M10934 2.17 0.018
Metabolism    
   Lipoprotein lipase L03294 2.72 0
   Ubiquitin carboxyl-terminal hydrolase D10699 3 0.003
Signal transduction    
   Thy-1 protein X02002 2.89 0.002
   CD3 gamma-chain S79711 3.28 0.002
   Synapsin M27925 3.94 0.001
   Alpha-actinin-2 associated LIM protein AF002281 2.74 0.009
   RESP18 L25633 2.74 0.033
   T3 delta protein X53430 2.75 0.003
   Protein phosphatase inhibitor-1 J05592t 2.6 0.009
   CART protein U10071 2.16 0.001
   Neuroendrocrine protein M63901 3.7 0.006
   Protein kinase C-binding protein Zeta1 U63740 3.14 0.003
   cannabinoid receptor 1 X55812 2.17 0.002
   Guanylyl cyclase A J05677 3.18 0.007
   Tachykinin 1 X56306 2.36 0.036
   Protein tyrosine phosphatase L19180 2.47 0.041
   Argininosuccinate synthetase X12459 4.69 0.004
Stress response/apoptosis    
   Small inducible cytokine Y08358 3.35 0.029
Structure proteins    
   Fast myosin alkali light chain L00088 4.52 0.03
   Light molecular-weight neurofilament AF031880 2.41 0
   Neurofilament protein middle Z12152 2.97 0.006
   Alpha-tubulin V01227 2.25 0
   Peripherin AF031878 2.82 0.007
Transcription factor/regulator    
   snRNP M29293 2.11 0.004
   snRNP-associated polypeptide X73411 3.33 0.002
Others    
   C1-13 gene product X52817 3.17 0
   ND5, ND6 S46798 2.31 0.015
   Sensory neuron synuclein X86789 2.84 0
  1. *Changes in gene expression were determined by t-test (DMT), comparative analysis (MAS 5.0), and SAM (Stanford). Gene expression profiles from CAS animals were used as control. P value and fold change are based on the DMT analysis; whereas listed genes met all of the analytical criteria as described in Methods.