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Table 4 Down-regulated genes in rats fed with SPI diet*

From: Dietary exposure to soy or whey proteins alters colonic global gene expression profiles during rat colon tumorigenesis

Category and Gene Name Probe Set GB Accession No. Fold Change P value
Cell adhesion    
   Embigin AJ009698 -5.13 0.001
Cell Cycle/growth control    
   FGF receptor activating protein 1 U57715 -5.59 0.002
   BEST5 protein Y07704 -2.37 0.003
   Peptide tyrosine-tyrosine (YY) M17523 -3.91 0.002
   Glucagon gene K02813 -6.58 0.002
   Epithelial membrane protein-1 Z54212 -3.47 0.017
   Neu oncogene X03362 -1.58 0.05
Defense/immunity protein    
   Beta defensin-1 AF068860 -42.16 0.001
  AF093536 -10.2 0
Detoxification/antioxidation    
   Glutathione S-transferase J02810 -7.14 0
   Glutathione S-transferase Yb X04229 -11.71 0.001
   Glutathione S-transferase, alpha 1 K01932 -4.18 0.004
   Glutathione S-transferase Yc1 S72505 -5.23 0.001
   Glutathione S-transferase Yc2 S72506 -5.27 0.012
  S82820 -3.45 0.006
   Cytochrome P450 4F4 (CYP4F4) U39206 -6.52 0.002
   Cytochrome P450CMF1b J02869 -4.12 0.002
   Cytochrome P450 (CYP4F1) M94548 -2.88 0.002
   1-Cys peroxiredoxin Y17295 -2.55 0.002
   Metallothionein M11794 -2.92 0.006
   D-amino-acid oxidase AB003400 -5.42 0
   Peroxiredoxin 6 AF014009 -3.07 0.008
   Phenylalanine hydroxylase M12337 -10.99 0.001
Metabolism    
   Dipeptidase L07315 -3.08 0.001
   Meprin beta-subunit M88601 -3.27 0.001
   Disintegrin and metalloprotease domain 7 X66140 -14.03 0
Ligand binding/carrier    
   Carnitine transporter AB017260 -3.81 0.003
   Chloride channel (ClC-2) AF005720 -3.26 0.001
   Putative potassium channel AF022819 -2.69 0.001
   Mitochondrial dicarboxylate carrier AJ223355 -2.54 0.01
   Aquaporin 3 D17695 -4.13 0
   Intestinal fatty acid binding protein K01180 -4.43 0.005
   Na_H_Exchanger L11236 -4.47 0.002
   H+, K+-ATPase M90398 -2.52 0.001
   Carbonic anhydrase IV S68245 -4.28 0.005
   Sodium transporter X59677 -3.4 0
   Phosphatidylethanolamine binding protein X75253 -2.69 0
Signal transduction    
   B7 antigen X76697 -170.95 0.002
   HCNP E05646 -3.38 0
   Itmap1 AF022147 -7.97 0.005
   Guanylate cyclase activator 2A M95493 -3.28 0.006
   Sgk L01624 -2.76 0
Stress response/apoptosis    
   Prostaglandin D synthetase J04488 -45.8 0.01
Structure proteins    
   Muc3 U76551 -3.56 0.01
   Intestinal mucin M76740 -3.31 0.006
   Mucin-like protein M81920 -3 0
   Plasmolipin Z49858 -2.92 0.003
Transcription factor/regulator    
   Testis specific X-linked gene X99797 -6.91 0.003
Others    
   Arginase II U90887 -3.22 0
   3-phosphoglycerate dehydrogenase X97772 -4.15 0.017
   Aldehyde dehydrogenase family 1 AF001898 -3.93 0.004
  1. *Changes in gene expression were determined by t-test (DMT), comparative analysis (MAS 5.0), and SAM (Stanford). Gene expression profiles from CAS animals were used as control. P value and fold-change are based on the DMT analysis; whereas genes listed above met all of the analytical criteria as described in Methods.