Skip to main content

Table 5 Up-regulated genes in rats fed with SPI diet*

From: Dietary exposure to soy or whey proteins alters colonic global gene expression profiles during rat colon tumorigenesis

Category and Gene Name Probe Set GB Accession No. Fold Change P value
Cell adhesion    
   Collagen alpha1 type I Z78279 2.49 0
   Secreted phosphoprotein 1 M14656 111.39 0.006
   Matrix metalloproteinase 13 M60616 24.34 0.002
   Regenerating islet M62930 193.08 0.011
Defense/immunity protein    
   Ig gamma-2a chain L22654 115.17 0.001
   Ig gamma heavy chain M28670 3.22 0
   Ig germline kappa-chain C-region M18528 2.48 0.038
   Ig light-chain U39609 2.63 0.021
   Fc-gamma M32062 4.72 0.017
Detoxification    
   Glutathione S-transferase 1 J03752 2.86 0
   Glutathione-S-transferase,alpha type2 K00136 2.56 0.009
   UDP glucuronosyltransferase D38066 2.83 0.014
Metabolism    
   Matrix metalloproteinase 7 L24374 3.63 0.02
   lysozyme rc_AA892775 2.77 0
   Matrix metalloproteinase 12 X98517 11.8 0.013
   Mitochondrial carbamyl phosphate synthetase I M12335 59.25 0.001
   Aldolase B, exon 9 X02291 8.7 0.01
   Aldolase B, exon 2 X02284 2.71 0.001
Signal transduction    
   MHC class II antigen RT1.B-1 beta-chain X56596 2.55 0.001
   CD3 gamma-chain S79711 4.51 0.001
Ligand binding/carrier    
   Intracellular calcium-binding protein L18948 28.29 0.014
   Retinol binding protein II M13949 5.11 0.001
   Apolipoprotein B M27440 6.47 0.024
   Apolipoprotein A-I J02597 2.49 0.004
   Iron ion transporter AF008439 18.78 0.008
Stress response/apoptosis    
   Heme oxygenase J02722 9.66 0.002
   JE product X17053 3.52 0.001
   Pancreatitis-associated protein M98049 68.39 0.004
   Pancreatitis associated protein III L20869 15.35 0
   Reg protein E01983 30.25 0.001
Others    
   Histamine N-tele-methyltransferase S82579 6.17 0.04
  1. *Changes in gene expression were determined by t-test (DMT), comparative analysis (MAS 5.0), and SAM (Stanford). Gene expression profiles from CAS animals were used as control. P value and fold-change are based on the DMT analysis; whereas final listed genes met all of the analytical criteria as described in the Methods.