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Table 5 Up-regulated genes in rats fed with SPI diet*

From: Dietary exposure to soy or whey proteins alters colonic global gene expression profiles during rat colon tumorigenesis

Category and Gene Name

Probe Set GB Accession No.

Fold Change

P value

Cell adhesion

   

   Collagen alpha1 type I

Z78279

2.49

0

   Secreted phosphoprotein 1

M14656

111.39

0.006

   Matrix metalloproteinase 13

M60616

24.34

0.002

   Regenerating islet

M62930

193.08

0.011

Defense/immunity protein

   

   Ig gamma-2a chain

L22654

115.17

0.001

   Ig gamma heavy chain

M28670

3.22

0

   Ig germline kappa-chain C-region

M18528

2.48

0.038

   Ig light-chain

U39609

2.63

0.021

   Fc-gamma

M32062

4.72

0.017

Detoxification

   

   Glutathione S-transferase 1

J03752

2.86

0

   Glutathione-S-transferase,alpha type2

K00136

2.56

0.009

   UDP glucuronosyltransferase

D38066

2.83

0.014

Metabolism

   

   Matrix metalloproteinase 7

L24374

3.63

0.02

   lysozyme

rc_AA892775

2.77

0

   Matrix metalloproteinase 12

X98517

11.8

0.013

   Mitochondrial carbamyl phosphate synthetase I

M12335

59.25

0.001

   Aldolase B, exon 9

X02291

8.7

0.01

   Aldolase B, exon 2

X02284

2.71

0.001

Signal transduction

   

   MHC class II antigen RT1.B-1 beta-chain

X56596

2.55

0.001

   CD3 gamma-chain

S79711

4.51

0.001

Ligand binding/carrier

   

   Intracellular calcium-binding protein

L18948

28.29

0.014

   Retinol binding protein II

M13949

5.11

0.001

   Apolipoprotein B

M27440

6.47

0.024

   Apolipoprotein A-I

J02597

2.49

0.004

   Iron ion transporter

AF008439

18.78

0.008

Stress response/apoptosis

   

   Heme oxygenase

J02722

9.66

0.002

   JE product

X17053

3.52

0.001

   Pancreatitis-associated protein

M98049

68.39

0.004

   Pancreatitis associated protein III

L20869

15.35

0

   Reg protein

E01983

30.25

0.001

Others

   

   Histamine N-tele-methyltransferase

S82579

6.17

0.04

  1. *Changes in gene expression were determined by t-test (DMT), comparative analysis (MAS 5.0), and SAM (Stanford). Gene expression profiles from CAS animals were used as control. P value and fold-change are based on the DMT analysis; whereas final listed genes met all of the analytical criteria as described in the Methods.