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Table 6 Genes co-regulated with WPH and SPI diet*

From: Dietary exposure to soy or whey proteins alters colonic global gene expression profiles during rat colon tumorigenesis

Category and Gene Name Probe Set GB Accession No. Fold Change in WPH P value Fold Change in SPI P value
Down-regulated genes      
   Embigin AJ009698 -6.57 0 -5.13 0.001
   Epithelial membrane protein 1 Z54212 -4.67 0.015 -3.47 0.017
   Glucagon K02813 -7.73 0.005 -6.58 0.002
   Peptide tyrosine-tyrosine (YY) M17523 -4.56 0.001 -3.91 0.002
   FGF receptor activating protein U57715 -4.25 0.002 -5.59 0.002
   Neu oncogene X03362 -2.61 0.017 -1.58 0.05
   CD52 antigen X76697 -170.95 0.002 -170.95 0.002
   Beta defensin-1 AF068860 -54.48 0.001 -42.16 0.001
   Glutathione S-transferase J02810 -5.17 0 -7.14 0
   Glutathione S-transferase Yb X04229 -9.33 0 -11.71 0.001
   Glutathione S-transferase, alpha 1 K01932 -3.07 0.002 -4.18 0.004
   Glutathione S-transferase Yc1 S72505 -3.69 0.004 -5.23 0.001
   Glutathione S-transferase Yc2 S72506 -21.38 0.008 -5.27 0.012
   Cytochrome P450CMF1b J02869 -8.23 0.001 -4.12 0.002
   Cytochrome P450 4F4 U39206 -6.43 0.004 -6.52 0.002
   Cytochrome P450IVF M94548 -5.78 0.002 -2.88 0.002
   D-amino-acid oxidase AB003400 -13.69 0 -5.42 0
   Meprin beta-subunit M88601 -5 0.004 -3.27 0.001
   Disintegrin and metalloprotease domain 7 X66140 -11.91 0 -14.03 0
   Carnitine transporter AB017260 -3.95 0.005 -3.81 0.003
   Chloride channel (ClC-2) AF005720 -5.69 0.002 -3.26 0.001
   Putative potassium channel AF022819 -4.84 0 -2.69 0.001
   Mitochondrial dicarboxylate carrier AJ223355 -3.55 0.009 -2.54 0.01
   Aquaporin 3 D17695 -7.83 0 -4.13 0
   Na_H_Exchanger L11236 -9.81 0.003 -4.47 0.002
   H+, K+-ATPase M90398 -13.87 0 -2.52 0.001
   Fatty acid binding protein 1 K01180 -7.29 0.001 -4.43 0.005
   Sodium transporter X59677 -3.8 0 -3.4 0
   Carbonic anhydrase IV S68245 -4.28 0.011 -4.28 0.005
   Itmap1 AF022147 -7.5 0.001 -7.97 0.005
   HCNP E05646 -2.5 0.001 -3.38 0
   Guanylate cyclase activator 2A M95493 -4.18 0.005 -3.28 0.006
   Sgk L01624 -3.93 0 -2.76 0
   Prostaglandin D synthetase J04488 -43.11 0.009 -45.8 0.01
   Mucin 3 M76740 -5.09 0.002 -3.31 0.006
   Mucin-like protein M81920 -11.97 0.001 -3 0
   Plasmolipin Z49858 -7.2 0 -2.92 0.003
Up-regulated genes      
   Ig gamma heavy chain M28670 2.21 0.009 3.22 0
   CD3 gamma-chain S79711 3.28 0.002 4.51 0.001
  1. *Changes in gene expression were determined by t-test (DMT), comparative analysis (MAS 5.0), and SAM (Stanford). Gene expression profiles from CAS animals were used as control. P value and fold change are based on the DMT analysis; whereas final listed genes met all of the analytical criteria described in Methods.