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Table 6 Genes co-regulated with WPH and SPI diet*

From: Dietary exposure to soy or whey proteins alters colonic global gene expression profiles during rat colon tumorigenesis

Category and Gene Name

Probe Set GB Accession No.

Fold Change in WPH

P value

Fold Change in SPI

P value

Down-regulated genes

     

   Embigin

AJ009698

-6.57

0

-5.13

0.001

   Epithelial membrane protein 1

Z54212

-4.67

0.015

-3.47

0.017

   Glucagon

K02813

-7.73

0.005

-6.58

0.002

   Peptide tyrosine-tyrosine (YY)

M17523

-4.56

0.001

-3.91

0.002

   FGF receptor activating protein

U57715

-4.25

0.002

-5.59

0.002

   Neu oncogene

X03362

-2.61

0.017

-1.58

0.05

   CD52 antigen

X76697

-170.95

0.002

-170.95

0.002

   Beta defensin-1

AF068860

-54.48

0.001

-42.16

0.001

   Glutathione S-transferase

J02810

-5.17

0

-7.14

0

   Glutathione S-transferase Yb

X04229

-9.33

0

-11.71

0.001

   Glutathione S-transferase, alpha 1

K01932

-3.07

0.002

-4.18

0.004

   Glutathione S-transferase Yc1

S72505

-3.69

0.004

-5.23

0.001

   Glutathione S-transferase Yc2

S72506

-21.38

0.008

-5.27

0.012

   Cytochrome P450CMF1b

J02869

-8.23

0.001

-4.12

0.002

   Cytochrome P450 4F4

U39206

-6.43

0.004

-6.52

0.002

   Cytochrome P450IVF

M94548

-5.78

0.002

-2.88

0.002

   D-amino-acid oxidase

AB003400

-13.69

0

-5.42

0

   Meprin beta-subunit

M88601

-5

0.004

-3.27

0.001

   Disintegrin and metalloprotease domain 7

X66140

-11.91

0

-14.03

0

   Carnitine transporter

AB017260

-3.95

0.005

-3.81

0.003

   Chloride channel (ClC-2)

AF005720

-5.69

0.002

-3.26

0.001

   Putative potassium channel

AF022819

-4.84

0

-2.69

0.001

   Mitochondrial dicarboxylate carrier

AJ223355

-3.55

0.009

-2.54

0.01

   Aquaporin 3

D17695

-7.83

0

-4.13

0

   Na_H_Exchanger

L11236

-9.81

0.003

-4.47

0.002

   H+, K+-ATPase

M90398

-13.87

0

-2.52

0.001

   Fatty acid binding protein 1

K01180

-7.29

0.001

-4.43

0.005

   Sodium transporter

X59677

-3.8

0

-3.4

0

   Carbonic anhydrase IV

S68245

-4.28

0.011

-4.28

0.005

   Itmap1

AF022147

-7.5

0.001

-7.97

0.005

   HCNP

E05646

-2.5

0.001

-3.38

0

   Guanylate cyclase activator 2A

M95493

-4.18

0.005

-3.28

0.006

   Sgk

L01624

-3.93

0

-2.76

0

   Prostaglandin D synthetase

J04488

-43.11

0.009

-45.8

0.01

   Mucin 3

M76740

-5.09

0.002

-3.31

0.006

   Mucin-like protein

M81920

-11.97

0.001

-3

0

   Plasmolipin

Z49858

-7.2

0

-2.92

0.003

Up-regulated genes

     

   Ig gamma heavy chain

M28670

2.21

0.009

3.22

0

   CD3 gamma-chain

S79711

3.28

0.002

4.51

0.001

  1. *Changes in gene expression were determined by t-test (DMT), comparative analysis (MAS 5.0), and SAM (Stanford). Gene expression profiles from CAS animals were used as control. P value and fold change are based on the DMT analysis; whereas final listed genes met all of the analytical criteria described in Methods.