A cluster of genes located in 1p36 are down-regulated in neuroblastomas with poor prognosis, but not due to CpG island methylation

Table 2 Putative promoter regions and CpG island predictions.

Gene	Promoter region	CpG island	Amplified region
UBE4B	-1212 to -492	-1157 to -150	-959 to -494
KIF1B	-22392 to -21141	-22444 to -20935	-22517 to -21874
PGD	-185 to +7	-680 to +728	-157 to +144
APITD1^a	-250 to +30	-389 to +643	-418 to +321
DFFA	+65 to +264	-164 to +256	-266 to +142
PEX14	-	-2806 to -2362	-2752 to -2481

^a For APITD1, the methylation status was analyzed for three different fragments. Column 2: Putative promoter regions according to Genomatix Promoter Inspector software. No promoter region was detected in PEX14. Column 3: CpG island prediction by MethPrimer (for CpG island criteria, see materials and methods). Column 4: Region amplified with the primers used in this study.

ISSN: 1476-4598