Table 1 Correlation between each of twelve putative chemoresistance transcript abundance values and chemoresistance among NSCLC cell lines. Eight of the 12 selected multi-drug resistance and DNA repair genes were significantly correlated with chemoresistance among the first group of 8 NSCLC cell lines evaluated (Group 1). In order to validate these results, an additional six lines were evaluated (Group 2).
| Â | Group 1a | Groups 1 and 2b | ||
|---|---|---|---|---|
Gene | R 2 | p value | R 2 | p value |
ABCC5 | 0.93 | 0.0001 | 0.85 | 0.0001 |
ERCC2 | 0.85 | 0.0012 | 0.82 | 0.0001 |
XPA | 0.81 | 0.0023 | 0.75 | 0.0001 |
LIG1 | 0.78 | 0.0034 | NAc | NA |
DDIT3 | 0.68 | 0.0120 | NA | NA |
ABCC1 | 0.64 | 0.0164 | NA | NA |
XRCC1 | 0.56 | 0.0318 | 0.57 | 0.0019 |
ERCC3 | 0.56 | 0.0319 | NA | NA |
ABCC4 | 0.37 | 0.1081 | NA | NA |
ABCC10 | 0.06 | 0.5641 | NA | NA |
GTF2H2 | 0.02 | 0.7424 | 0.04 | 0.5183 |
XPC | 0.00 | 0.9851 | 0.02 | 0.6654 |