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Figure 6 | Molecular Cancer

Figure 6

From: Regulation of pancreatic cancer cell migration and invasion by RhoC GTPase and Caveolin-1

Figure 6

Effect of disruption of caveolae and mis-localization of caveolin-1 after treatment of BxPC-3 cells with MβCD. A. Results of a colloidal gold random motility assay performed after a 1 h pre-treatment of BxPC-3 cells with 5 mM MβCD in growth medium. Phagokinetic tracks were measured 16 h after stimulation. MβCD treated BxPC-3 cells were significantly more migratory than untreated cells (* p = 0.0001) B. Total (light grey) and active GTP-bound (dark grey) levels of RhoC were measured in MβCD treated BxPC-3 cells 3 h after treatment. A statistical difference in RhoC activation was reached with a p value of 0.0001. C. Immunoblot analysis of basal levels of active (light grey) and total (dark grey) p42/p44 Erk and p38 MAPK in MβCD treated BxPC-3 cells 3 h after treatment.

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