|
Toxicity
|
4 patients at each dose level (mg/kg)
|
|---|
| |
20
|
30
|
40
|
|
Depressed level of consciousness*
|
3 (g2)
|
3(g2)
|
1(g1), 3(g2)
|
|
Nausea
|
-
|
1 (g1), 1(g2)
|
1 (g2)
|
|
Diarrhea
|
-
|
-
|
-
|
|
Fatigue
|
3 (g2)
|
1(g2)
|
-
|
|
Anorexia
|
-
|
1(g2)
|
-
|
|
Dizziness/lightheadedness
|
-
|
1(g2)
|
-
|
- *Grade 2 toxicity. All others were grade 1.
- Depressed level of consciousness (g1: somnolence or sedation not interfering with function; g2: somnolence or sedation interfering with function but not interfering with activities of daily living; g3: obtundation or stupor, difficulty to arouse, interfering with daily living; g4) coma.
