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Table 1 Transcript abundance measurements for cultured normal BEC and BC cell lines

From: Variation in transcriptional regulation of cyclin dependent kinase inhibitor p21waf1/cip1 among human bronchogenic carcinomas

Sample

Cell Type

Medium

Genetic Alterations

Transcript Abundance

   

p53

p16

p14 ARF

Rb

p73

c-myc

E2F1

p73α

p21

17378B

N

B

      

1,500

1

21,000

6F0333B

N

B

      

4,700

1

76,000

6F0395B

N

B

      

5,100

1

120,000

SW900

Sq

R

 

I

    

7,300

100

12,000

Calu-1

Sq

R

I

I

    

8,500

28

2,000

H460

LC

R

 

I

    

9,000

14

18,000

H82

SC

R

I

 

I

I

 

A

15,000

17

400

A549

A

R

 

I

I

   

16,000

1

6,200

A2126

A

R

I

     

17,000

30

6,100

N417

SC

R

I

  

I

 

A

19,000

5,200

34,000

H322

BA

R

I

I

    

20,000

190

31,000

H446

SC

R

   

I

 

A

67,000

710

120,000

H1155*

LC

R

I

  

I

I

 

50,000

250

470

H520

Sq

R

I

I

    

56,000

120

2,300

H146

SC

R

   

I

  

59,000

700

19,000

H661

LC

R

I

I

    

76,000

210

58,000

A427**

A

R

 

I

    

180,000

220

100,000

  1. N, normal; Sq, squamous carcinoma; LC, large cell carcinoma; SC, small cell carcinoma; A, adenocarcinoma; BA, bronchoalveolar carcinoma; B, BEGM medium; R, RPMI with 10% FBS; I, inactivated; A, amplification. Non-detectable TA were entered as 1 to allow plotting on a logarithmic scale. Cell lines are grouped by increasing E2F1 TA. All values are in units of molecules/106 molecules β-actin and represent the mean from three independent measurements. *H1155 has a missense mutation in the transactivation domain of p73. **A427 has a deletion in the p73 coding sequence but the protein product still retains its transactivational function [35].
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Molecular Cancer

ISSN: 1476-4598