From: Tumor suppressor in lung cancer 1 (TSLC1) alters tumorigenic growth properties and gene expression
Gene | Up-Regulated | Assay | Fold Expression Difference | Functional Class |
---|---|---|---|---|
Fibrinogen beta chain (FGB) | A549 | SH/qPCR | 2737.5+/-1058.5 | Adhesion |
Fibrinogen gamma chain (FGG) | A549 | SH | ND | Adhesion |
Adenomatosis polyposis coli (APC)* | A549 | qPCR | 1.7+/-0.2 | Cellular Growth |
Cyclin D1 (CCND1)†| A549 | qPCR | 1.6+/-0.0 | Cellular Growth |
β-catenin 1 (CTNNB1)* | 12.2 | qPCR | 1.1+/-0.0 | Cellular Growth |
Dishevelled 1 (DVL1)* | A549 | qPCR | 1.1+/-0.3 | Cellular Growth |
v-Ha-ras Harvey rat sarcoma viral oncogene homolog (HRAS)†| A549 | qPCR | 1.4+/-0.3 | Cellular Growth |
Lymphoid enhancer-binding factor 1 (LEF1)* | 12.2 | qPCR | 3.4+/-0.4 | Cellular Growth |
v-myc myelocytomatosis viral oncogene homolog (MYC)†| A549 | qPCR | 1.3+/-0.2 | Cellular Growth |
Interleukin 23-alpha (p19)†| A549 | qPCR | 1.0+/-0.0 | Cellular Growth |
Tumor protein p53 (TP53)†| A549 | qPCR | 1.7+/-0.3 | Cellular Growth |
Retinoblastoma 1 (RB1)†| 12.2 | qPCR | 1.3+/-0.4 | Cellular Growth |
S100 calcium-binding protein P (S100P) | A549 | SH/qPCR | 1680.0+/-955.4 | Cellular Growth |
Transcription factor 4 (TCF4)* | 12.2 | qPCR | 6.8+/-2.0 | Cellular Growth |
Transcription factor 7-like 2 (TCF7L2)* | 12.2 | qPCR | 2.2+/-0.7 | Cellular Growth |
Transmembrane 4 superfamily member (TM4SF4) | A549 | SH/qPCR | 475.2+/-328.0 | Cellular Growth |
Centromere protein E (CENPE) | A549 | SH | Â | Cellular Growth |
Heat shock protein 70B (HSPA6) | A549 | SH/qPCR | 2.4+/-0.8 | Chaperone |
Insulin-like growth factor binding protein 1 (IGFBP1) | A549 | SH/qPCR | 15.9+/-7.4 | Decidualization [41] |
Retinoid X receptor RXR (DR-1) | A549 | TS | 2.7 | Decidualization [42] |
Aldehyde dehydrogenase 1 (ALDH1) | A549 | SH/qPCR | 4.2+/-0.1 | Decidualization-Implantation [43] |
Annexin A2 (Lipocortin II) (ANXA2) | 12.2 | SH/qPCR | 3.1+/-1.0 | Decidualization-Implantation [43] |
Metallothionein-IF (MTIF) | 12.2 | SH | ND | Decidualization-Implantation [43] |
Metallothionein-IG (MT1G) | 12.2 | SH/qPCR | 37.1+/-10.4 | Decidualization-Implantation [43] |
Cadherin 11 (OB-cadherin, osteoblast) (CDH11) | A549 | SH/qPCR | 5.6+/-2.7 | Decidualization-Luteal/Adhesion [34,44] |
Fibroblast growth factor 9 (FGF9) | A549 | SH | ND | Decidualization-Proliferation [45] |
Promyelocytic leukemia gene (PML) | A549 | SH | ND | Decidualization-Proliferation |
Similar to aldehyde dehydrogenase 6 (ALDH1A3) | A549 | SH | ND | Dehydrogenase |
3-alpha hydroxysteroid dehydrogenase type II (AKR1C3) | A549 | SH | ND | Dehydrogenase |
Dihydrodiol dehydrogenase 2 (AKR1C2) | A549 | SH/qPCR | 22.9+/-2.4 | Dehydrogenase |
Kinesin 2, light chain (KNS2) | 12.2 | SH/qPCR | 3.9+/-0.0 | Intracellular Trafficking |
Matrix metalloproteinase 1 (MMP1) | 12.2 | qPCR | 1.2+/-0.4 | Invasion |
Vascular endothelial growth factor (VEGF) | 12.2 | qPCR | 4.2+/-0.3 | Invasion |
Ferritin, heavy chain (FTH1) | 12.2 | SH/qPCR | 2.7+/-1.7 | Iron Binding |
Metallothionein-IE (MT1E) | 12.2 | SH/qPCR | 14.8+/-8.5 | Metal Homeostasis |
Metallothionein-IH (MT1H) | 12.2 | SH | ND | Metal Homeostasis |
Metallothionein-IL (MT1L) | 12.2 | SH/qPCR | 5.8+/-0.9 | Metal Homeostasis |
Metallothionein-IR (MT1R) | 12.2 | SH | ND | Metal Homeostasis |
Manganese-containing superoxide dismutase (SOD2) | A549 | SH/qPCR | 2.0+/-0.6 | Mitochondrial |
Microsomal glutathione transferase (MGST1) | A549 | SH/qPCR | 2.3+/-0.1 | Mitochondrial |
NAD(P)H menadione oxidoreductase 1, dioxin-inducible (NQO1) | A549 | SH/qPCR | 3.1+/-0.1 | Mitochondrial |
Solute carrier family 25 member 5 (SLC25A5) | A549 | SH/qPCR | 3.4+/-0.3 | Mitochondrial |
Myelin proteolipid protein (PLP) | A549 | SH | ND | Myelin Constituent |
Ribosomal protein S6 (RPS6) | 12.2 | SH/qPCR | 2.5+/-1.2 | Protein Kinase |
v-ets erythroblastosis virus E26 oncogene homolog 2 (ETS2) | A549 | qPCR | 1.2+/-0.0 | Ras-Induced Senescence [29] |
Metallothionein-II (MTII) | 12.2 | SH | ND | Ras-Induced Senescence [29] |
Ras induced senescence 1 (RIS1) | 12.2 | SH/qPCR | 80.2+/-62.3 | Ras-Induced Senescence [29] |
Tissue inhibitor of metalloproteinase 1 (TIMP1) | 12.2 | qPCR | 2.2+/-0.1 | Ras-Induced Senescence [29] |
CAAT box general (CBF) | 12.2 | TS | 2.5 | Transcription Factor |
CCAAT displacement protein (CDP) | 12.2 | TS | 2 | Transcription Factor |
E2F transcription factor 1 (E2F-1) | 12.2 | TS | 2.4 | Transcription Factor |
Early growth response (EGR) | 12.2 | TS | 3.4 | Transcription Factor |
Estrogen receptor (ERE) | 12.2 | TS | 2.5 | Transcription Factor |
GATA binding protein (GATA) | 12.2 | TS | 2.1 | Transcription Factor |
Glucocorticoid receptor (GRE) | 12.2 | TS | 3 | Transcription Factor |
Nuclear factor of activated T-cells, cytoplasmic (NF-ATc) | 12.2 | TS | 3.1 | Transcription Factor |
Signal transducer and activator or transcription 3 (STAT3) | A549 | TS | 2 | Transcription Factor |
Signal transducer and activator or transcription 4 (STAT4) | A549 | TS | 2.3 | Transcription Factor |
Upstream transcription factor (USF-1) | A549 | TS | 2.5 | Transcription Factor |
Transcription co-activator Sp110 | A549 | SH | ND | Transcription Factor |
Similar to eukaryotic translation initiation factor 2B, subunit 1 (EIF2B1) | A549 | SH | ND | Translation |
Insulin-like 4 (INSL4) | A549 | SH/qPCR | 27.0+/-15.8 | Trophoblast [46] |
Keratin 8 (KRT8) | A549 | SH | ND | Trophoblast [47] |
cDNA clone DKFZp761C1(AL157447) | A549 | SH | ND | Unknown |
cDNA clone FLJ20643 (AK000650) | A549 | SH | ND | Unknown |
FLJ14639 (NM_032815) | A549 | SH | ND | Unknown |
Hit clone 451B21 (AL033522) | A549 | SH | ND | Unknown |
HSA1p34 genomic sequence (AL009181) | A549 | SH | ND | Unknown |
Rhomboid family 1 (Z69719) (RHBDF1) | A549 | SH | ND | Unknown |
RP11-2H8 (AC089984) | A549 | SH | ND | Unknown |
RP11-389E6 (AL359836) | A549 | SH | ND | Unknown |
RP11-478J18 (AC011700) | A549 | SH | ND | Unknown |
RP11-7F24 (AC018841) | A549 | SH | ND | Unknown |
RP1-20C7 (AL136304) | A549 | SH | ND | Unknown |
SR+89 (Z69706) | A549 | SH | ND | Unknown |
HSA14 genomic sequence (AL135745) | 12.2 | SH | ND | Unknown |