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Table 1 ZIP1 immuno-positivity of glandular components in tissue sections of confirmed cases of prostate cancer.

From: hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer

Case no. Grade ZIP1 IHC scorea
   Normal PIN BPH Malignant
1 3 +++   +++ Negative
2 3   + ++ +
3 1   Negative + Negative
4 2    + Negative
5 2    Negative Negative
6 1 Negative   +++ Negative
7 2 ++   + +
8 1    +++ +
9 1 ++   +++ Negative
10 2    +++ Negative
11 1    ++ Negative
12 2    Negative Negative
13 1    ++ +
14 1    + Negative
15 1    + Negative
16 1   Negative + Negative
17 2    +++ +
18 1   + ++ +
19 1    + Negative
20 1    + Negative
21 2   + +++ +
22 1    Negative Negative
NEG ZIP1 IHC    3/22 (14%) 15/22 (68%)*
SCORES > + 3/4 0/6 11/22 0/22*
MEAN SCOREb 1.75 0.6 1.68(1.09) 0.32(0.48)*
  1. aScoring of immunoreactivity was done as follows: negative, no positive cells; score +, <10% positive cells; score ++, 10–50% positive cells; score +++, >50% positive cells
  2. bMEAN SCORE: MEAN(SD) for each group was obtained by the sum of the +'s/number of cases.
  3. * P < 0.01; BPH VS MALIGNANT GROUPS