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Table 2 Tumor suppressor genes hypermethylated in invasive cervical cancer

From: Epigenetics of cervical cancer. An overview and therapeutic perspectives

Gene Rate Function Reference
DcR1/DcR2 100% Apoptosis 113
hTERT 57% Apoptosis 122
p73 39% Apoptosis 129
p16 8–42% Cell-cycle 130–136
PTEN 58% WNT-pathway 142
E-cadherin 28–80.5% WNT-pathway 143–145
APC 11–94% WNT-pathway 133,135,136
MGMT 5–81% DNA repair 133,134,136,144
FANCF 30% FA-BRAC pathway 161
BRAC1 6.1% FA-BRAC pathway 133
hMLH1 5% Mismatch repair 134
RASSF1A 0–45% Negative ras-effector 144,172–174
DAPK 45–100% Metastasis/cell death 133,135,136,144
TSLC1 58–65% Tumor suppressor 179,180
FHIT 11–88% DNA repair?/cell death? 133,134,135,136,144
HIC1 18–45% Transcription factor 133,135
RARβ 33–66% Cell differentiation 133,136,200,201
TIMP2/TIMP3 47%/1–10% Tissue inhibitor MTs 144,202,203
Caveolin-1 6% Caveolae membrane 205
ER α 25% Steroid hormone receptor 136