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Table 3 Translational opportunities from epigenetic alterations in cervical cancer

From: Epigenetics of cervical cancer. An overview and therapeutic perspectives

Early detection Identification of a set of hypermethylated genes from cytological smears
Prognostic/predictive Determination of global methylation or histone modifications in tumor or peripheral blood cells Determination of hypermethylated gene promoters from serum/plasma DNA
Therapy DNA methylation inhibitors and/or HDACs inhibitors alone or as chemo- or radio-sensitizers