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Table 5 Main findings of epigenetic therapy in cervical cancer

From: Epigenetics of cervical cancer. An overview and therapeutic perspectives

Lack of response to DNA methylation inhibitor 5-aza-2-deoxycytidine as a single agent in advanced or recurrent cervical cancer*
Response rate of 38.1% with the DNA methylation inhibitor 5-aza-2-deoxycytidine plus cisplatin in advanced or recurrent cervical cancer*
Demethylation and reactivation of the expression of several tumor suppressor genes in the tumors of cervical cancer patients in a phase I trial of the DNA methylation inhibitor hydralazine
Sustained stabilization of disease in a patient with cervical cancer treated within a phase I trial of the HDAC inhibitor MS-275
Major response in a patient with cervical cancer being treated with the HDAC inhibitor valproic acid followed by a single dose of epirubicin within a phase I trial
H3 and H4 hyperacetylation as well as inhibition of deacetylase activity in the tumors of cervical cancer patients with cervical cancer in a phase I trial of the HDAC inhibitor magnesium valproate
Ongoing phase II trial of the combination of hydralazine and magnesium valproate added to cisplatin chemoradiation in FIGO stage IIIB patients
  1. *DNA methylation was not analyzed in these trials.