Figure 1From: Metallothionien 3 expression is frequently down-regulated in oesophageal squamous cell carcinoma by DNA methylationSchematic diagram of the MT3 promoter. The diagram was generated by downloading the MT3 CpG island genetic element with the addition of 200 bases upstream from http://genome.ucsc.edu/, using the Human July 2003 Freeze. The location of 5' UTR (â–¡), exon 1 and exon 2 (â– ) of MT3 (NM_005954) are shown. Each vertical line represents a CpG. The arrows represent the location of the 12 BstUI restriction enzyme sites analysed. The regions amplified for the 3 COBRA PCRs, R1, R2 and R3, are shown.Back to article page