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Table 4 Genes significantly increased in tumors.

From: Global gene expression in neuroendocrine tumors from patients with the MEN1 syndrome

GeneBank Accession

Gene

Symbol

Normal Mean

Tumor Mean

Fold Change

P value

 

Cell Growth/Cycle

     

X16323

hepatocyte growth factor

HGF

11

116

10.77

0.003305

AB017642

oxidative-stress responsive 1

OSR1

58

428

7.41

0.000819

AL078641

phorbolin-like protein

APOBEC3G

15

92

6.21

0.000158

L17128

gamma-glutamyl carboxylase

GGCX

64

346

5.37

0.000018

D21089

xeroderma pigmentosum, complementation group C

XPC

292

1278

4.38

0.000284

AL050223

vesicle-associated membrane protein 2

VAMP2

360

1533

4.26

0.002196

D38145

prostaglandin I2 synthase

PTGIS

29

121

4.09

0.000448

AF092563

structural maintenance of chromosomes 2-like 1

SMC2L1

58

185

3.21

0.002352

AF006087

actin related protein 2/3 complex, subunit 4

ARPC4

292

865

2.96

0.000565

AC004537

inhibitor of growth family, member 3

ING3

46

114

2.47

0.003976

AF013168

tuberous sclerosis 1

TSC1

35

86

2.45

0.001232

AJ236876

ADP-ribosyltransferase polymerase)-like 2

ADPRTL2

32

76

2.34

0.003874

 

Cell Death/Apoptosis

     

D38435

postmeiotic segregation increased 2-like

PMS2L1

74

193

2.6

0.002976

M61906

phosphoinositide-3-kinase, regulatory subunit

PIK3R1

43

104

2.4

0.004387

 

Signal Transduction

     

U26710

Cas-Br-M ectropic retroviral transforming sequence b

CBLB

21

177

8.4

0.000082

AB010414

guanine nucleotide binding protein, gamma 7

GNG7

59

334

5.68

0.003835

U59913

mothers against decapentaplegic homolog 5

MADH5

14

73

5.22

0.004731

AB004922

Homo sapiens gene for Smad 3

MADH3

93

443

4.76

0.001024

L11672

zinc finger protein 91

ZNF91

428

2007

4.69

0.000376

D14838

fibroblast growth factor 9

FGF9

27

108

3.97

0.000752

W27899

member RAS oncogene family

RAB6B

68

232

3.43

0.00501

U48251

protein kinase C binding protein 1

PRKCBP1

40

127

3.18

0.001999

U90268

cerebral cavernous malformations 1

CCM1

53

151

2.87

0.004392

AL050275

cysteine rich with EGF-like domains

CRELD1

195

543

2.79

0.000828

AB014600

SIN3 homolog B, transcriptional regulator

SIN3B

177

425

2.39

0.001924

M27691

cAMP responsive element binding protein 1

CREB1

107

229

2.15

0.003559

U85245

phosphatidylinositol-4-phosphate 5-kinase, type II, beta

PIP5K2B

244

518

2.12

0.000441

W25793

ring finger protein 3

RNF3

163

326

2

0.004947

 

Nucleic Acid Binding

     

D50912

RNA binding motif protein 10

RBM10

96

443

4.6

0.001925

U41315

makorin, ring finger protein, 4

MKRN4

404

808

2

0.000262

 

Ligand Binding

     

X67155

kinesin-like 5

KIF23

64

368

5.76

0.001584

AB028985

ATP-binding cassette, sub-family A, member 2

ABC1

65

262

4.04

0.001234

Z48482

matrix metalloproteinase 15

MMP15

139

495

3.56

0.003946

 

Enzyme

     

X13794

lactate dehydrogenase B

LDHB

396

1606

4.05

0.000845

X15334

creatine kinase, brain

CKB

939

2083

2.22

0.002008

X60708

dipeptidylpeptidase IV

DPP4

133

291

2.19

0.000697

AC004381

SA homolog

SAH

283

599

2.11

0.000168

AF000416

exostoses-like 2

EXTL2

134

271

2.02

0.001314

 

Embryogenesis

     

U48437

amyloid beta precursor-like protein 1

APLP1

851

2433

2.86

0.001043

U66406

ephrin-B3

EFNB3

168

438

2.6

0.00309

D50840

UDP-glucose ceramide glucosyltransferase

UGCG

85

211

2.5

0.002554

 

Other/Unknown

     

L48215

hemoglobin, beta

HBB

12

2099

178.78

0.001299

J00153

hemoglobin, alpha 1

HBA1

15

1249

82.25

0.001889

U30521

P311 protein

C5orf13

157

453

2.88

0.001431

AB011169

similar to S. cerevisiae SSM4

TEB4

140

300

2.15

0.00154

AL031432

GCIP-interacting protein

P29

99

198

2

0.002036