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Table 4 Genes significantly increased in tumors.

From: Global gene expression in neuroendocrine tumors from patients with the MEN1 syndrome

GeneBank Accession Gene Symbol Normal Mean Tumor Mean Fold Change P value
  Cell Growth/Cycle      
X16323 hepatocyte growth factor HGF 11 116 10.77 0.003305
AB017642 oxidative-stress responsive 1 OSR1 58 428 7.41 0.000819
AL078641 phorbolin-like protein APOBEC3G 15 92 6.21 0.000158
L17128 gamma-glutamyl carboxylase GGCX 64 346 5.37 0.000018
D21089 xeroderma pigmentosum, complementation group C XPC 292 1278 4.38 0.000284
AL050223 vesicle-associated membrane protein 2 VAMP2 360 1533 4.26 0.002196
D38145 prostaglandin I2 synthase PTGIS 29 121 4.09 0.000448
AF092563 structural maintenance of chromosomes 2-like 1 SMC2L1 58 185 3.21 0.002352
AF006087 actin related protein 2/3 complex, subunit 4 ARPC4 292 865 2.96 0.000565
AC004537 inhibitor of growth family, member 3 ING3 46 114 2.47 0.003976
AF013168 tuberous sclerosis 1 TSC1 35 86 2.45 0.001232
AJ236876 ADP-ribosyltransferase polymerase)-like 2 ADPRTL2 32 76 2.34 0.003874
  Cell Death/Apoptosis      
D38435 postmeiotic segregation increased 2-like PMS2L1 74 193 2.6 0.002976
M61906 phosphoinositide-3-kinase, regulatory subunit PIK3R1 43 104 2.4 0.004387
  Signal Transduction      
U26710 Cas-Br-M ectropic retroviral transforming sequence b CBLB 21 177 8.4 0.000082
AB010414 guanine nucleotide binding protein, gamma 7 GNG7 59 334 5.68 0.003835
U59913 mothers against decapentaplegic homolog 5 MADH5 14 73 5.22 0.004731
AB004922 Homo sapiens gene for Smad 3 MADH3 93 443 4.76 0.001024
L11672 zinc finger protein 91 ZNF91 428 2007 4.69 0.000376
D14838 fibroblast growth factor 9 FGF9 27 108 3.97 0.000752
W27899 member RAS oncogene family RAB6B 68 232 3.43 0.00501
U48251 protein kinase C binding protein 1 PRKCBP1 40 127 3.18 0.001999
U90268 cerebral cavernous malformations 1 CCM1 53 151 2.87 0.004392
AL050275 cysteine rich with EGF-like domains CRELD1 195 543 2.79 0.000828
AB014600 SIN3 homolog B, transcriptional regulator SIN3B 177 425 2.39 0.001924
M27691 cAMP responsive element binding protein 1 CREB1 107 229 2.15 0.003559
U85245 phosphatidylinositol-4-phosphate 5-kinase, type II, beta PIP5K2B 244 518 2.12 0.000441
W25793 ring finger protein 3 RNF3 163 326 2 0.004947
  Nucleic Acid Binding      
D50912 RNA binding motif protein 10 RBM10 96 443 4.6 0.001925
U41315 makorin, ring finger protein, 4 MKRN4 404 808 2 0.000262
  Ligand Binding      
X67155 kinesin-like 5 KIF23 64 368 5.76 0.001584
AB028985 ATP-binding cassette, sub-family A, member 2 ABC1 65 262 4.04 0.001234
Z48482 matrix metalloproteinase 15 MMP15 139 495 3.56 0.003946
  Enzyme      
X13794 lactate dehydrogenase B LDHB 396 1606 4.05 0.000845
X15334 creatine kinase, brain CKB 939 2083 2.22 0.002008
X60708 dipeptidylpeptidase IV DPP4 133 291 2.19 0.000697
AC004381 SA homolog SAH 283 599 2.11 0.000168
AF000416 exostoses-like 2 EXTL2 134 271 2.02 0.001314
  Embryogenesis      
U48437 amyloid beta precursor-like protein 1 APLP1 851 2433 2.86 0.001043
U66406 ephrin-B3 EFNB3 168 438 2.6 0.00309
D50840 UDP-glucose ceramide glucosyltransferase UGCG 85 211 2.5 0.002554
  Other/Unknown      
L48215 hemoglobin, beta HBB 12 2099 178.78 0.001299
J00153 hemoglobin, alpha 1 HBA1 15 1249 82.25 0.001889
U30521 P311 protein C5orf13 157 453 2.88 0.001431
AB011169 similar to S. cerevisiae SSM4 TEB4 140 300 2.15 0.00154
AL031432 GCIP-interacting protein P29 99 198 2 0.002036