Table 6 Genes significantly decreased in tumors (continued).
From: Global gene expression in neuroendocrine tumors from patients with the MEN1 syndrome
GeneBank Accession | Gene Description | Symbol | Normal Mean | Tumor Mean | Fold Change | P value |
|---|---|---|---|---|---|---|
| Â | Signal Transduction | Â | Â | Â | Â | Â |
J00306 | somatostatin | SST | 7701 | 284 | -27.09 | 0 |
AI636761 | somatostatin | SST | 7224 | 598 | -12.09 | 0.000001 |
AB011143 | GRB2-associated binding protein 2 | GAB2 | 2237 | 402 | -5.57 | 0.001816 |
M93056 | serine (or cysteine) proteinase inhibitor | SERPINB1 | 505 | 105 | -4.80 | 0.004637 |
X68830 | islet amyloid polypeptide | IAPP | 2231 | 477 | -4.68 | 0.001221 |
AB029014 | RAB6 interacting protein 1 | RAB6IP1 | 824 | 181 | -4.56 | 0.000155 |
AI198311 | neuropeptide Y | NPY | 610 | 154 | -3.96 | 0.004817 |
M28210 | member RAS oncogene family | RAB3A | 2566 | 672 | -3.82 | 0.000048 |
J04040 | glucagon | GCG | 8620 | 2351 | -3.67 | 0.000396 |
AF030335 | purinergic receptor P2Y | P2RY11 | 2314 | 680 | -3.40 | 0.000058 |
M29335 | major histocompatibility complex | HLA-DOA | 906 | 268 | -3.39 | 0.00159 |
L38517 | Indian hedgehog homolog | IHH | 3013 | 897 | -3.36 | 0.000055 |
U95367 | gamma-aminobutyric acid A receptor, pi | GABRP | 668 | 202 | -3.30 | 0.000837 |
W28558 | pleiotropic regulator 1 | PLRG1 | 704 | 216 | -3.26 | 0.000068 |
L08485 | gamma-aminobutyric acid A receptor, alpha 5 | GABRA5 | 342 | 107 | -3.20 | 0.000336 |
AF004231 | leukocyte immunoglobulin-like receptor | LILRB2 | 93 | 30 | -3.08 | 0.001105 |
AF055033 | insulin-like growth factor binding protein 5 | IGFBP5 | 126 | 43 | -2.96 | 0.000257 |
AJ010119 | ribosomal protein S6 kinase | RPS6KA4 | 1532 | 522 | -2.94 | 0.000201 |
U46194 | Human renal cell carcinoma antigen | RAGE | 2057 | 754 | -2.73 | 0.000324 |
L13858 | son of sevenless homolog 2 | SOS2 | 964 | 354 | -2.72 | 0.000268 |
Z29572 | tumor necrosis factor receptor superfamily | TNFRSF17 | 184 | 68 | -2.69 | 0.000178 |
U01134 | fms-related tyrosine kinase 1 | FLT1 | 910 | 379 | -2.40 | 0.003257 |
D78156 | RAS p21 protein activator 2 | RASA2 | 327 | 144 | -2.26 | 0.002332 |
U77783 | glutamate receptor | GRIN2D | 518 | 240 | -2.15 | 0.001379 |
D49394 | 5-hydroxytryptamine receptor 3A | HTR3A | 197 | 98 | -2.02 | 0.002493 |
| Â | Nucleic Acid Binding | Â | Â | Â | Â | Â |
Z30425 | nuclear receptor subfamily 1, group I, member 3 | NR1I3 | 1008 | 356 | -2.83 | 0.000329 |
U18760 | nuclear factor I/X | NFIX | 5796 | 2216 | -2.62 | 0.000711 |
AI223140 | purine-rich element binding protein A | PURA | 1137 | 506 | -2.25 | 0.002448 |
AF015950 | telomerase reverse transcriptase | TERT | 561 | 255 | -2.20 | 0.002839 |
U40462 | zinc finger protein, subfamily 1A, 1 | ZNFN1A1 | 662 | 308 | -2.15 | 0.001171 |
Z93930 | X-box binding protein 1 | XBP1 | 2223 | 1061 | -2.09 | 0.000277 |
AB019410 | PET112-like | PET112A | 1422 | 707 | -2.01 | 0.001309 |
| Â | Ligand Binding | Â | Â | Â | Â | Â |
X00129 | retinol binding protein 4, plasma | RBP4 | 1517 | 68 | -22.27 | 0.004809 |
AJ223317 | sarcosine dehydrogenase | SARDH | 3844 | 1069 | -3.60 | 0.000085 |
AB017494 | LCAT-like lysophospholipase | LYPLA3 | 906 | 326 | -2.78 | 0.001131 |
U78735 | ATP-binding cassette, sub-family A, member 3 | ABCA3 | 1914 | 706 | -2.71 | 0.000288 |
AF026488 | spectrin, beta, non-erythrocytic 2 | SPTBN2 | 1604 | 671 | -2.39 | 0.00005 |
U83659 | ATP-binding cassette, sub-family C, member 3 | ABCC3 | 1287 | 551 | -2.34 | 0.00244 |
R93527 | metallothionein 1H | MT1H | 5093 | 2196 | -2.32 | 0.002937 |
AA586894 | S100 calcium binding protein A7 | S100A7 | 507 | 221 | -2.29 | 0.000537 |
U91329 | kinesin family member 1C | KIF1C | 2981 | 1484 | -2.01 | 0.000518 |