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Table 6 Genes significantly decreased in tumors (continued).

From: Global gene expression in neuroendocrine tumors from patients with the MEN1 syndrome

GeneBank Accession Gene Description Symbol Normal Mean Tumor Mean Fold Change P value
  Signal Transduction      
J00306 somatostatin SST 7701 284 -27.09 0
AI636761 somatostatin SST 7224 598 -12.09 0.000001
AB011143 GRB2-associated binding protein 2 GAB2 2237 402 -5.57 0.001816
M93056 serine (or cysteine) proteinase inhibitor SERPINB1 505 105 -4.80 0.004637
X68830 islet amyloid polypeptide IAPP 2231 477 -4.68 0.001221
AB029014 RAB6 interacting protein 1 RAB6IP1 824 181 -4.56 0.000155
AI198311 neuropeptide Y NPY 610 154 -3.96 0.004817
M28210 member RAS oncogene family RAB3A 2566 672 -3.82 0.000048
J04040 glucagon GCG 8620 2351 -3.67 0.000396
AF030335 purinergic receptor P2Y P2RY11 2314 680 -3.40 0.000058
M29335 major histocompatibility complex HLA-DOA 906 268 -3.39 0.00159
L38517 Indian hedgehog homolog IHH 3013 897 -3.36 0.000055
U95367 gamma-aminobutyric acid A receptor, pi GABRP 668 202 -3.30 0.000837
W28558 pleiotropic regulator 1 PLRG1 704 216 -3.26 0.000068
L08485 gamma-aminobutyric acid A receptor, alpha 5 GABRA5 342 107 -3.20 0.000336
AF004231 leukocyte immunoglobulin-like receptor LILRB2 93 30 -3.08 0.001105
AF055033 insulin-like growth factor binding protein 5 IGFBP5 126 43 -2.96 0.000257
AJ010119 ribosomal protein S6 kinase RPS6KA4 1532 522 -2.94 0.000201
U46194 Human renal cell carcinoma antigen RAGE 2057 754 -2.73 0.000324
L13858 son of sevenless homolog 2 SOS2 964 354 -2.72 0.000268
Z29572 tumor necrosis factor receptor superfamily TNFRSF17 184 68 -2.69 0.000178
U01134 fms-related tyrosine kinase 1 FLT1 910 379 -2.40 0.003257
D78156 RAS p21 protein activator 2 RASA2 327 144 -2.26 0.002332
U77783 glutamate receptor GRIN2D 518 240 -2.15 0.001379
D49394 5-hydroxytryptamine receptor 3A HTR3A 197 98 -2.02 0.002493
  Nucleic Acid Binding      
Z30425 nuclear receptor subfamily 1, group I, member 3 NR1I3 1008 356 -2.83 0.000329
U18760 nuclear factor I/X NFIX 5796 2216 -2.62 0.000711
AI223140 purine-rich element binding protein A PURA 1137 506 -2.25 0.002448
AF015950 telomerase reverse transcriptase TERT 561 255 -2.20 0.002839
U40462 zinc finger protein, subfamily 1A, 1 ZNFN1A1 662 308 -2.15 0.001171
Z93930 X-box binding protein 1 XBP1 2223 1061 -2.09 0.000277
AB019410 PET112-like PET112A 1422 707 -2.01 0.001309
  Ligand Binding      
X00129 retinol binding protein 4, plasma RBP4 1517 68 -22.27 0.004809
AJ223317 sarcosine dehydrogenase SARDH 3844 1069 -3.60 0.000085
AB017494 LCAT-like lysophospholipase LYPLA3 906 326 -2.78 0.001131
U78735 ATP-binding cassette, sub-family A, member 3 ABCA3 1914 706 -2.71 0.000288
AF026488 spectrin, beta, non-erythrocytic 2 SPTBN2 1604 671 -2.39 0.00005
U83659 ATP-binding cassette, sub-family C, member 3 ABCC3 1287 551 -2.34 0.00244
R93527 metallothionein 1H MT1H 5093 2196 -2.32 0.002937
AA586894 S100 calcium binding protein A7 S100A7 507 221 -2.29 0.000537
U91329 kinesin family member 1C KIF1C 2981 1484 -2.01 0.000518