Table 7 Genes significantly decreased in tumors (continued).
From: Global gene expression in neuroendocrine tumors from patients with the MEN1 syndrome
GeneChip Accession | Gene Description | Symbol | Normal Mean | Tumor Mean | Fold Change | P value |
|---|---|---|---|---|---|---|
| Â | Enzyme | Â | Â | Â | Â | Â |
M81057 | carboxypeptidase B1 | CPB1 | 4534 | 79 | -57.09 | 0.001106 |
X71345 | protease, serine, 4 | PRSS3 | 3859 | 76 | -51.11 | 0.004102 |
X01683 | serine (or cysteine) proteinase inhibitor, clade A | SERPINA1 | 2550 | 74 | -34.64 | 0.004833 |
M24400 | chymotrypsinogen B1 | CTRB1 | 5158 | 207 | -24.95 | 0.001744 |
M18700 | elastase 3A, pancreatic | ELA3A | 7058 | 384 | -18.37 | 0.000009 |
U66061 | protease, serine, 1 | PRSS1 | 7291 | 645 | -11.31 | 0.000047 |
L22524 | matrix metalloproteinase 7 | MMP7 | 595 | 54 | -11.03 | 0.002591 |
AI655458 | 5-oxoprolinase (ATP-hydrolysing) | OPLAH | 446 | 99 | -4.52 | 0.004072 |
H94881 | FXYD domain-containing ion transport regulator 2 | FXYD2 | 3116 | 708 | -4.40 | 0.000539 |
AL021026 | flavin containing monooxygenase 2 | FMO2 | 905 | 215 | -4.21 | 0.000804 |
AC005525 | plasminogen activator, urokinase receptor | PLAUR | 1779 | 566 | -3.14 | 0.000031 |
U40370 | phosphodiesterase 1A, calmodulin-dependent | PDE1A | 268 | 89 | -3.03 | 0.004023 |
R90942 | sialyltransferase 7D | SIAT7D | 3148 | 1052 | -2.99 | 0.002319 |
M84472 | hydroxysteroid (17-beta) dehydrogenase 1 | HSD17B1 | 1196 | 440 | -2.72 | 0.000991 |
X55988 | ribonuclease, RNase A family, 2 | RNASE2 | 480 | 203 | -2.36 | 0.001314 |
AB003151 | carbonyl reductase 1 | CBR1 | 4538 | 1945 | -2.33 | 0.000511 |
X08020 | glutathione S-transferase M1 | GSTM1 | 2766 | 1376 | -2.01 | 0.000519 |
| Â | Embryogenesis | Â | Â | Â | Â | Â |
U15979 | delta-like homolog | SIGLEC5 | 3384 | 402 | -8.41 | 0.002927 |
M60094 | H1 histone family, member T | HIST1H1T | 976 | 230 | -4.23 | 0.001639 |
U50330 | bone morphogenetic protein 1 | BMP1 | 3298 | 973 | -3.39 | 0.001637 |
M74297 | homeo box A4 | HOXA4 | 501 | 176 | -2.85 | 0.000477 |
AJ011785 | sine oculis homeobox homolog 6 | SIX6 | 530 | 190 | -2.79 | 0.000286 |
U66198 | fibroblast growth factor 13 | FGF13 | 191 | 73 | -2.61 | 0.001068 |
D31897 | double C2-like domains, alpha | DOC2A | 1151 | 451 | -2.55 | 0.000068 |
U12472 | glutathione S-transferase pi | GSTP1 | 3122 | 1524 | -2.05 | 0.000237 |
| Â | Transcription | Â | Â | Â | Â | Â |
AL049228 | pleckstrin homology domain interacting protein | PHIP | 257 | 33 | -7.69 | 0.000782 |
M27878 | zinc finger protein 84 | ZNF84 | 54 | 15 | -3.64 | 0.001108 |
U77629 | achaete-scute complex-like 2 | ASCL2 | 438 | 184 | -2.38 | 0.000058 |
D50495 | transcription elongation factor A, 2 | TCEA2 | 1330 | 595 | -2.23 | 0.000019 |
U49857 | transcriptional activator of the c-fos promoter | CROC4 | 542 | 259 | -2.09 | 0.003894 |