Table 2 Expression of mucins (MUC2, MUCSAC and MUC6) in H. pylori infected pre-neoplastic and neoplastic human gastric epithelium
Stages | H. pylori | MUC2 Expression | MUC5AC Expression | MUC6 Expression | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | N | P | - | + | ++ | +++ | ++++ | - | + | ++ | +++ | ++++ | - | + | ++ | +++ | ++++ |
Normal (n = 7) | 7 | - | n = 7 (100%) | - | - | - | - | - | - | - | n = 2 (28.6%) | n = 5 (71.4%) | - | - | - | 1 (14.3%) | 6 (85.7%) |
Atrophic gastritis (n = 26) | - | 26 | n = 22 (84.6%) | n = 4 (15.4%) | - | - | - | - | - | 1 (38%) | 13 (50%) | 12 (46.2%) | - | - | 1 (3.8%) | 15 (57.7%) | 10 (38.5%) |
Intestinal metaplasia (n = 21) | - | 21 | - | - | n = 9 (42.9%) | n = 12 (57.1%)** | - | - | 1 (4.8%) | 16 (76.2%)** | 4 (19%) | - | - | 5 (23.8%) | 14 (66.7%)** | 2 (9.5%) | - |
Dysplasia (n = 17) | - | 17 | - | n = 5 (29.4%) | n = 11 (64.7%) | n = 1 (5.9%) | - | - | 3 (17.6%) | 10 (58.8%) | 4 (23.5%) | - | - | 3 (17.6%) | 11 (64.7%) | 3 (17.3%) | - |
Carcinoma (n = 36) | - | 36 | - | 22 (61.1%) | 14 (38.9%) | - | - | - | 28 (77.8%) | 8 (22.2%) | - | - | 12 (33.3%) | 17 (47.2%) | 7 (19.4%) | - | - |