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Table 2 Expression of mucins (MUC2, MUCSAC and MUC6) in H. pylori infected pre-neoplastic and neoplastic human gastric epithelium

From: Expression profile of mucins (MUC2, MUC5AC and MUC6) in Helicobacter pylori infected pre-neoplastic and neoplastic human gastric epithelium

Stages H. pylori MUC2 Expression MUC5AC Expression MUC6 Expression
  N P - + ++ +++ ++++ - + ++ +++ ++++ - + ++ +++ ++++
Normal (n = 7) 7 - n = 7 (100%) - - - - - - - n = 2 (28.6%) n = 5 (71.4%) - - - 1 (14.3%) 6 (85.7%)
Atrophic gastritis (n = 26) - 26 n = 22 (84.6%) n = 4 (15.4%) - - - - - 1 (38%) 13 (50%) 12 (46.2%) - - 1 (3.8%) 15 (57.7%) 10 (38.5%)
Intestinal metaplasia (n = 21) - 21 - - n = 9 (42.9%) n = 12 (57.1%)** - - 1 (4.8%) 16 (76.2%)** 4 (19%) - - 5 (23.8%) 14 (66.7%)** 2 (9.5%) -
Dysplasia (n = 17) - 17 - n = 5 (29.4%) n = 11 (64.7%) n = 1 (5.9%) - - 3 (17.6%) 10 (58.8%) 4 (23.5%) - - 3 (17.6%) 11 (64.7%) 3 (17.3%) -
Carcinoma (n = 36) - 36 - 22 (61.1%) 14 (38.9%) - - - 28 (77.8%) 8 (22.2%) - - 12 (33.3%) 17 (47.2%) 7 (19.4%) - -
  1. N – negative - (> 5%) negative
  2. P – positive + (5–25%) few positive cells
  3. n – No. of cases ++ (25–50%) well-defined area
  4. +++ (50–75%) extensive area stained
  5. ++++ (75–100%) most of the cells stained
  6. **p < 0.00, *p < 0.05 (Significant difference in expression)