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Table 1 Selected genes derived from ICA & GO analysis of gene array experiments. Genes are combined into ontologies. Average Fold Changes are calculated from normalised values over the number of spots shown for each gene. As can be seen, not all genes are differentially expressed according to t-test p-values. Genes are instead selected based on their ICA loading (see discussion)

From: In vitro and in vivo effects of the PPAR-alpha agonists fenofibrate and retinoic acid in endometrial cancer

GO Description Gene symbol Description No of spots Ave FC Ave ttest p
activation of MAPKKK (GO:0000185) GADD45B growth arrest and DNA-damage-inducible, beta 2 2.6 0.090
cell cycle arrest (GO:0007050) EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 2 1.2 0.249
  GADD45A growth arrest and DNA-damage-inducible, alpha 2 5.1 0.003
  PPP1R15A protein phosphatase 1, regulatory (inhibitor) subunit 15A 2 1.4 0.085
  PR48 protein phosphatase 2A 48 kDa regulatory subunit 1 -1.1 0.427
  SESN3 sestrin 3 2 -1.3 0.161
  TP53 tumor protein p53 (Li-Fraumeni syndrome) 4 1.7 0.036
cell death (GO:0008219) EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 2 1.2 0.249
  EMP3 epithelial membrane protein 3 2 1.7 0.111
cell growth (GO:0016049) P8 p8 protein (candidate of metastasis 1) 2 3.1 0.005
  SLC3A2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 4 2.0 0.012
cell proliferation (GO:0008283) EGFR epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) 2 2.2 0.009
  FTH1 ferritin, heavy polypeptide 1 1 1.2 0.301
  IGFBP4 insulin-like growth factor binding protein 4 2 1.8 0.002
  OSMR oncostatin M receptor 2 1.7 0.088
  PDGFA platelet-derived growth factor alpha polypeptide 2 1.5 0.032
  PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 4 2.2 0.083
  SYK spleen tyrosine kinase 2 -1.1 0.631
  TGFA transforming growth factor, alpha 2 -1.0 0.907
  TGFBI transforming growth factor, beta-induced, 68kDa 2 2.1 0.164
  TP53 tumor protein p53 (Li-Fraumeni syndrome) 4 1.7 0.036
  VEGF vascular endothelial growth factor 2 6.6 0.175
G1/S transition of mitotic cell cycle (GO:0000082) CCND1 cyclin D1 (PRAD1: parathyroid adenomatosis 1) 2 -1.3 0.168
insulin-like growth factor binding (GO:0005520) CYR61 cysteine-rich, angiogenic inducer, 61 2 2.9 0.013
  KAZALD1 Kazal-type serine protease inhibitor domain 1 2 -1.1 0.770
  IGFBP4 insulin-like growth factor binding protein 4 2 1.8 0.002
  CTGF connective tissue growth factor 2 2.9 0.006
  IGFBP5 insulin-like growth factor binding protein 5 4 2.7 0.041
metalloprotease inhibitor (GO:0008191) TIMP1 tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) 3 1.4 0.250
methionine adenosyltransferase (GO:0004478) MAT2A methionine adenosyltransferase II, alpha 4 -2.9 0.001
methionine-tRNA ligase (GO:0004825) MARS methionine-tRNA synthetase 2 6.7 0.006