Celecoxib and DMC decrease levels of survivin protein in various cancer cell lines. Several different cancer cell lines were cultured in the presence of celecoxib (Cxb) and DMC for 48 hours as indicated. Total cellular lysates were prepared and analyzed by Western blot analysis with specific antibodies to survivin. As a control for equal loading, all blots were also analyzed with antibodies to actin (only two of these control blots are shown at the bottom). The tumor type of each cell line is indicated on the right.