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Figure 3 | Molecular Cancer

Figure 3

From: Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo

Figure 3

Downregulation of survivin is specific to celecoxib and DMC and correlates with reduced survival. U251 glioblastoma or BxPc-3 pancreatic carcinoma cells were cultured in the presence of DMC, various non-steroidal anti-inflammatory drugs (NSAIDs), or solvent DMSO alone, at the concentrations indicated. Cell growth and survival was determined by standard MTT assay (top part of figure). In parallel, total cellular lysates were prepared and analyzed by Western blot analysis with specific antibodies to survivin or to actin as a loading control (bottom part of figure).

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Molecular Cancer

ISSN: 1476-4598