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Figure 5 | Molecular Cancer

Figure 5

From: The p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancers

Figure 5

Model outlining the role of hCdc14A as a p53-targeting phosphatase. The ser315 site of p53 can be phosphorylated by aurora kinase A and the Cdk1/cyclin B complex. In this study we show evidence that hCdc14A can antagonize these kinases by dephosphorylating the ser315 site in cells. In addition, by interacting with Cdk1/cyclin B during interphase, hCdc14A may further antagonize Cdk1/cyclin B-mediated phosphorylation until cells enter mitosis.

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Molecular Cancer

ISSN: 1476-4598