Figure 4
From: Methylation mediated silencing of TMS1/ASC gene in prostate cancer
Binding pattern of acetylated histones (panel A) and MBD's (panel B) to the methylated TMS1/ASC gene. Chromatin immunoprecipitation performed on formalin fixed and sonicated LNCaP chromatin shows enrichment of MBD3 in the immunoprecipitated DNA and low levels of acetylated H3 suggesting deacetylation of H3 in the silenced TMS1/ASC gene.