Figure 2

The relative scores (0–4+) of HIF-1α levels in 28 squamous carcinomas of the tongue analyzes by immunohistochemistry and scanned using NIH image software. a) HIF-1α negative, N, no polyporphisms or mutations identified for HIF-1α, or TSC1 or TSC2; b) HIF-1α positive (2.1 ± .45), N, no polyporphisms or mutations identified for HIF-1α, or TSC1 or TSC2; c) HIF-1α positive (3.3 ± .3), P/M, HIF-1α polymorphism or mutation, N, no polymorphism or mutation in TSC1 or TSC2; d) HIF-1α positive (4.0), P/M, HIF-1α polymorphism mutation + TSC deletion or mutation;e) HIF-1α positive (2.9 ± .4), N, no polyporphisms or mutations identified for HIF-1α, TSC deletion or mutation. (*, P < 0.05)