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Figure 3 | Molecular Cancer

Figure 3

From: Down-regulation of c-Myc following MEK/ERK inhibition halts the expression of malignant phenotype in rhabdomyosarcoma and in non muscle-derived human tumors

Figure 3

Cell cycle arrest by MadMyc chimera expression in RD cells. A. Cell lysates from polyclonal population of CMV, MadMyc chimera and c-Myc transiently and stably transfected RD cells were analysed by immunoblotting with c-Myc monoclonal antibody recognising both c-Myc and MadMyc chimera proteins. Same filters were re-probed with pospho-ERKs, ERKs and α-tubulin antibodies. B. Growth curve of polyclonal populations of RD cells stably transfected with MadMyc chimera (), c-Myc (), and CMV (). Polyclonal populations of stably transfected RD cells were plated and counted at indicated times. The data show the mean ± s.e.m. of triplicates of a representative experiment. Similar results were obtained in two experiments.

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