A genome-wide map of aberrantly expressed chromosomal islands in colorectal cancer

Table 4 Expression in Islands frequently deleted in CRC.

*chromosomal region*	*fraction of patients with deletions*	*congruent with our expression data*	*CGH study*
1p		yes	[17]
1p36.2-1p36.1	21%	yes	[22]
1p21-1p22	72%	no	[21, 24]
3p12	66%	no	[21, 24]
4	–	yes	[15, 17, 18]
4p	42%	yes	[19]
4p14	87%	yes	[21, 24]
4q	58%	yes	[19]
4q27-4q28	96%	no	[21, 24]
4q31.3	39%	no	[22]
4q34.3	38%	yes	[25]
4q35	34%	yes	[22]
5q	> 35%	yes	[17, 23]
5q21	81%	yes	[21, 24]
6q16-6q21	72%	no	[21, 24]
8p	37%	no	[17, 18, 23, 25]
8p24-8p21	66%	no	[21, 24]
9p21	64%	yes	[21, 24]
9p22	25%	no	[22]
10q26.2	22%	no	[25]
11q13.1	30%	no	[25]
14q		yes	[17]
14q13-14q21	64%	yes	[21, 24]
15q		yes	[17]
17p	46%	yes	[23]
17p13.2	51%	yes	[25]
17p12	32%	yes	[25]
18		yes	[17]
18p	49%	yes	[23]
18q	60%	yes	[23]
18q	32%	yes	[18, 25]
18q	92%	yes	[19]
18q11.2	72%	no	[22]
18q12.2	59%	no	[25]
18q21-18q23	96%	yes	[21]
18q21.1	60%	yes	[25]
21q	> 35%	yes	[23]
21q21	74%	no	[21, 24]

Literature survey of chromosomal regions with evidence for deletions in colorectal cancers. We checked all regions of frequent chromosomal deletions for congruence with expression patterns. Congruence between literature CGH data and our expression data was declared on the presumption that allelic loss causes mRNA down-regulation.

ISSN: 1476-4598