A genome-wide map of aberrantly expressed chromosomal islands in colorectal cancer

Table 3 Expression in Islands frequently amplified in CRC.

*chromosomal region*	*fraction of patients*	*congruence with our expression data*	*CGH study*
1		no	[18]
1q21	57%	no	[21]
3p25.2	30%	yes	[25]
3q26.31	32%	no	[25]
6p12.1	24%	no	[25]
7	46%	yes	[17, 18, 25]
7p	> 35%	yes	[23]
7p	42%	yes	[19]
7p22.3	57%	yes	[25]
7q	42%	yes	[19]
7q	> 35%	yes	[23]
7q11.2-7q12	75%	7q11.23-7q21.3	[21, 24]
8q		yes	[17]
8q	27%	yes	[18, 25]
8q	42%	yes	[23]
8q24	57%	yes	[21]
8q24.21	40%	yes	[25]
8q24.22	30%	yes	[25]
8q24.3	51%	yes	[25]
9q34	67%	9q31.11	[21, 24]
11q	> 35%	yes	[23]
12p13.1-12p13.2	22%	down at 12p13.31-12p13-2	[25]
13		yes	[18]
13	46%	yes	[25]
13q		yes	[17]
13q13	64%	no	[21, 24]
13q34	64%	no	[21]
15q22-15q23		down at 15q21.1-15q22.31	[22]
16p12-11	70%	down at 16p12.1-16p11.2	[21, 24]
16p13.3	49%	no	[25]
16q23.2	24%	no	[25]
17q	42%	yes	[19]
17q12-17q21		yes	[24]
17q12	22%	no	[25]
17q21	59%	yes	[21]
17q21.32	24%	yes	[25]
17q25.3	43%	no	[25]
19p13	70%	yes	[21, 24]
20		yes	[18, 25]
20p	58%	yes	[19]
20q		yes	[17]
20q	65%	yes	[23]
20q	100%	yes	[21]
20q	92%	yes	[19]
20q13.3	56%	yes	[22]
20q13.3	81%	yes	[25]
20q11.2-20q13.2		yes	[24]
22q11	61%	22q11.21-22q21.1	[21]
22q13.2	24%	no	[25]

Literature survey of chromosomal regions with evidence for amplifications in colorectal cancers. We checked all regions of frequent chromosomal amplifications for congruence with expression patterns. Congruence between literature CGH data and our expression data was declared on the presumption that allelic gain causes mRNA up-regulation.

ISSN: 1476-4598