Table 1 Changes in transcript levels of genes associated with mitotic progression after pRb acute loss
From: RB acute loss induces centrosome amplification and aneuploidy in murine primary fibroblasts
Symbol | Stat. Value | Description | Function |
|---|---|---|---|
Stmn1 | 11,1 | stathmin 1 | microtubule depolymerization mitotic spindle assembly |
Ckap2 | 8,74 | cytoskeleton associated protein 2 | microtubule stabilization |
Nusap1 | 8,45 | nucleolar and spindle associated protein 1 | positive regulation of mitosis |
Prc1 | 7,06 | protein regulator of cytokinesis 1 | mitotic spindle midzone associated-Cdk dependent |
Ccnf | 6,76 | cyclin F | cell cycle, mitosis |
Ccnb2 | 6,57 | cyclin B2 | regulation of cell cycle |
Anln | 6,18 | anillin, actin binding protein (scraps homolog, Drosophila) | cytokinesis |
Cdc20 | 6,14 | cell division cycle 20 homolog (S. cerevisiae) | cytokinesis |
Smc2l1 | 6,11 | SMC2 structural maintenance of chromosomes 2-like 1 (yeast) | mitotic chromosome condensation |
Ccnb1 | 5,98 | cyclin B1 | DNA replication |
Smc4l1 | 5,91 | SMC4 structural maintenance of chromosomes 4-like 1 (yeast) | chromosome segregation and organitation, cytokinesis |
Plk4 | 5,61 | polo-like kinase 4 (Drosophila) | cell cycle and centrosome homeostasis |
Cdc2a | 5,45 | cell division cycle 2 homolog A (S. pombe) | mitotic G2 checkpoint |
Mdm2 | 5,41 | transformed mouse 3T3 cell double minute 2 | traversing start control point of mitotic cell cycle |
Mki67 | 5,34 | antigen identified by monoclonal antibody Ki 67 | meiosis, cell proliferation |
Rad21 | 5,08 | RAD21 homolog (S. pombe) | cytokinesis, DNA repair, apoptosis, mitosis |
Cdk2 | 5,01 | cyclin-dependent kinase 2 | cytokinesis, cell cycle, mitosis |
Stk6 | 4,95 | aurora kinase A | cell cycle and centrosome homeostasis |
Anapc5 | 4,81 | anaphase-promoting complex subunit 5 | cytokinesis, ubiquitin cycle, cell cycle, mitosis |
Pttg1 | 4,54 | pituitary tumor-transforming (securin) | cell cycle, chromosome segregation, mitosis |
Plk1 | 4,44 | polo-like kinase 1 (Drosophila) | cell cycle and centrosome homeostasis |
Mad2l1 | 4,38 | MAD2 (mitotic arrest deficient, homolog)-like 1 (yeast) | mitotic sister chromatid segregation, cytokinesis, mitotic spindle checkpoint |
Cks2 | 4,15 | CDC28 protein kinase regulatory subunit 2 | cytokinesis, cell cycle |
Rbbp4 | 4,11 | retinoblastoma binding protein 4 | transcription |
Ccna2 | 3,94 | cyclin A2 | regulation of cell cycle, cytokinesis |
Nek2 | 3,7 | NIMA (never in mitosis gene a)-related expressed kinase 2 | mitotic sister chromatid segregation, cytokinesis, mitosis |
Ccne1 | 3,11 | cyclin E1 | regulation of progression through cell cycle, DNA replication |
Brca1 | 2,52 | Breast Cancer Associated Protein 1 | DNA repair, apoptosis, mitosis |