Table 3 Frequent copy number and expression altered genes1.
GAINED AND OVEREXPRESSED GENES | ||||
|---|---|---|---|---|
SYMBOL | GENE DESCRIPTION | % | MEDIAN | LOCATION |
ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 20.00 | 1.17 | 1q25-q32 |
LOC153222 | Adult retina protein | 25.00 | 1.32 | 5 |
GBAS | Glioblastoma amplified sequence | 20.00 | 1.61 | 7p12 |
GUSB | Glucuronidase, beta | 20.00 | 1.42 | 7q21.11 |
RFC2 | Replication factor C (activator 1) 2, 40kDa | 26.32 | 1.06 | 7q11.23 |
MCM7 | MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) | 35.29 | 1.02 | 7q21.3-q22.1 |
GIMAP6 | GTPase, IMAP family member 6 | 20.00 | 1.29 | |
LR8 | LR8 protein | 21.05 | 2.34 | 7q36.1 |
APOE | Apolipoprotein E | 22.22 | 1.48 | 19q13.2 |
EMP3 | Epithelial membrane protein 3 | 33.33 | 1.36 | 19q13.3 |
FPR1 | Formyl peptide receptor 1 | 25.00 | 1.94 | 19q13.4 |
LOST AND UNDEREXPRESSED GENES | ||||
SYMBOL | GENE DESCRIPTION | % | MEDIAN | LOCATION |
CYP1B1 | Cytochrome P450, family 1, subfamily B, polypeptide 1 | 21.05 | -2.87 | 2p21 |
TDE2 | Tumor differentially expressed 2 | 23.53 | -1.86 | 6q22.32 |
OPTN | Optineurin | 41.18 | -1.86 | 10p14 |
DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 | 25.00 | -1.16 | 10 |
SIRT1 | Sirtuin (silent mating type information regulation 2 homolog) 1 | 27.27 | -1.27 | 10q22.1 |
PPP3CB | Protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform | 35.00 | -2.08 | 10q21-q22 |
GHITM | Growth hormone inducible transmembrane protein | 37.50 | -1.55 | 10q23.2 |
CYP26A1 | Cytochrome P450, family 26, subfamily A, polypeptide 1 | 21.05 | -1.08 | 10q23-q24 |
LGI1 | Leucine-rich, glioma inactivated 1 | 45.00 | -1.32 | 10q24 |
SLK | STE20-like kinase (yeast) | 26.32 | -1.11 | 10q25.1 |
ADD3 | Adducin 3 (gamma) | 68.42 | -1.04 | 10q24.2-q24.3 |
MXI1 | MAX interactor 1 | 40.00 | -1.11 | 10q24-q25 |
ATRNL1 | Attractin-like 1 | 30.77 | -1.65 | 10 |
KIAA1598 | KIAA1598 | 21.05 | -1.83 | 10q26.12 |
NDFIP2 | Nedd4 family interacting protein 2 | 33.33 | -1.22 | 13q22.2 |
MAP2K4 | Mitogen-activated protein kinase kinase 4 | 23.53 | -1.30 | 17p11.2 |
DSG2 | Desmoglein 2 | 31.25 | -1.94 | 18q12.1 |
TPTE | Transmembrane phosphatase with tensin homology | 22.22 | -1.67 | 21p11 |