Expression of full-length p53 and its isoform Δp53 in breast carcinomas in relation to mutation status and clinical parameters

Table 2 p53 or Δp53 relative mRNA expression

	Wild type (Wt)		Mutation group I (MI) missense and in frame mutations		Mutation group II (MII) nonsense, frame shift and splice mutations
	No. of patients	Mean a.u. (± SEM) Median	No. of patients	Mean a.u. (± SEM) Median	No. of patients	Mean a.u. (± SEM) Median	Groups	p
full-length p53	50	0.770 (± 0.059)	27	1.310 (± 0.116)	11	0.496 (± 0.100)	Wt-MI-MII ¹	p < 0.00002
							Wt-MI²	p < 0.0002
		0.753		1.159		0.357	Wt-MII²	p < 0.04
							MI-MII²	p < 0.002
Δp53	61	0.790 (± 0.061)	15	1.171 (± 0.162)	11	0.482 (± 0.101)	Wt-MI-MII ¹	p < 0.004
							Wt-MI²	p < 0.04
		0.725		0.974		0.310	Wt-MII²	p < 0.02
							MI-MII²	p < 0.002

ISSN: 1476-4598