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Table 3 Relationship between wild-type full-length p53 mRNA expression level and clinical, pathological and biological factors

From: Expression of full-length p53 and its isoform Δp53 in breast carcinomas in relation to mutation status and clinical parameters

     wild-type full-length p53 RNA level   
     Q1 (<25%) Q2 & Q3 (25–75%) Q4 (>75%)   
Characteristic   Total No. Total (%) No. of patients (%) No. of patients (%) No. of patients (%) Groups p
Estrogen receptor status Negative 10 20 4 30.8 1 4.2 5 38.5 Q1-Q2/3-Q4 1 p < 0.03
  Positive 40 80 9 69.2 23 95.8 8 61.5 Q1-Q2/32 p < 0.03
           Q1-Q42 n.s.
           Q2/3-Q42 p < 0.009
Progesterone receptor status Negative 13 26 3 23.1 3 12.5 7 53.8 Q1-Q2/3-Q4 1 p < 0.03
  Positive 37 74 10 76.9 21 87.5 6 46.2 Q1-Q2/32 n.s.
           Q1-Q42 n.s.
           Q2/3-Q42 p < 0.009
ERBB2/HER status Negative 29 80.6 9 75.0 13 86.7 7 77.8 Q1-Q2/3-Q4 1 n.s.
  Positive 7 19.4 3 25.0 2 13.3 2 22.2 Q1-Q2/32 n.s.
           Q1-Q42 n.s.
           Q2/3-Q42 n.s.
Grade 1 5 10.0 0 0.0 2 8.3 3 23.1 Q1-Q2/3-Q4 1 p < 0.003
  2 24 48.0 2 15.4 15 62.5 7 53.8 Q1-Q2/32 p < 0.003
  3 21 42.0 11 84.6 7 29.2 3 23.1 Q1-Q42 p < 0.003
           Q2/3-Q42 n.s.
Subgroups Luminal A 25 53.2 1 9.1 18 75.0 6 50.0 Q1-Q2/3-Q4 1 p < 0.007
  Luminal B 6 12.8 3 27.3 0 0.0 3 25.0 Q1-Q2/32 p < 0.003
  ERBB2 7 14.9 3 27.3 3 12.5 1 8.3 Q1-Q42 p < 0.05
  Basal 4 8.5 2 18.2 1 4.2 1 8.3 Q2/3-Q42 n.s.
  Normal-like 5 10.6 2 18.2 2 8.3 1 8.3   
  1. 1 for Q1-Q2/3-Q4 the Kruskal Wallis test was performed
  2. 2 for Q1-Q2/3 the Mann-Whitney test was performed
  3. 2 for Q1-Q4 the Mann-Whitney test was performed
  4. 2 for Q2/3-Q4 the Mann-Whitney test was performed