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Table 4 p53 or Δp53 mutant classes and their relation to molecular subgroups*

From: Expression of full-length p53 and its isoform Δp53 in breast carcinomas in relation to mutation status and clinical parameters

   Wild type (Wt) Mutation group I (MI) missense and in frame mutations Mutation group II (MII) nonsense, frame shift and splice mutations   
   No. of patients (%) No. of patients (%) No. of patients (%) Groups p
full-length p53 Luminal A 25 53.2 4 15.4 0 0.0 Wt-MI-MII 1 p < 0.006
  Luminal B 6 12.8 6 23.1 3 27.3 Wt-MI2 p < 0.02
  ERBB2 7 14.9 7 26.9 4 36.4 Wt-MII2 p < 0.008
  Basal 4 8.5 9 34.6 3 27.3 MI-MII2 n.s.
  Normal-like 5 10.6 0 0.0 1 9.1 Wt-MI&MII2 p < 0.002
Δp53 Luminal A 27 46.6 2 13.3 0 0.0 Wt-MI-MII 1 p < 0.04
  Luminal B 8 13.8 4 26.7 3 27.3 Wt-MI2 n.s. (p < 0.07)
  ERBB2 10 17.2 3 20.0 5 45.5 Wt-MII2 p < 0.03
  Basal 8 13.8 6 40.0 2 18.2 MI-MII2 n.s.
  Normal-like 5 8.6 0 0.0 1 9.1   
  1. 1 for WT-MI-MII the Kruskal Wallis test was performed
  2. 2 for WT-MI the Mann-Whitney test was performed
  3. * The tumors have previously been subjected to whole genome microarray analysis and classified into subgroups according to their expression profile (see Material and Methods)