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Figure 2 | Molecular Cancer

Figure 2

From: Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors

Figure 2

Mesothelin primarily binds to MUC16 on the OVCAR-3cell surface. (A)MUC16 expression on the parental OVCAR-3 and the sublines #7, #9, and #12 was determined by flow cytometry using the VK-8 antibody. (B) Meso-Fc binding to the OVCAR-3 cells and the sublines #7, #9, and #12 was determined by flow cytometry using a GAR-FITC reporter antibody. (C-E) The MB antibody was used to determine meso-Fc binding to #7 (C), #9 (D), and #12 (E) and compared to expression of native mesothelin and MUC16 on the surface of these cells.

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