Table 4 Comparison of results obtained from this study with those based on Gene Ontology Processes by Sandberg et al. [7]
From: Pathway-specific differences between tumor cell lines and normal and tumor tissue cells
KEGG Pathway | Related GO category | Direction of regulation in cell lines with respect to tumors | |
|---|---|---|---|
| Â | Â | This study | Gene Ontology Study [7] |
ATP synthesis | ATP synthesis coupled proton transport (GO:0015986) | ↑ | ↑ |
Cell cycle | Cell cycle (GO:0007049) | ↑ | ↑ |
One carbon pool by folate | Nucleotide biosynthesis (GO:0009165) | ↑ | ↑ |
Oxidative phosphorylation | Oxidative phosphorylation (GO:0006119) | ↑ | ↑ |
Proteasome | Ubiquitin-dependent protein catabolism (GO:0006511); Modification-dependent protein catabolism (GO:0019941) | ↑ | ↑ |
Purine metabolism | Purine nucleotide metabolism (GO:0006163) | ↑ | ↑ |
Pyrimidine metabolism | Nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0006139) | ↑ | ↑ |
Ribosome | Protein biosynthesis (GO:0006412) | ↑ | ↑ |
RNA polymerase | Nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0006139) | ↑ | ↑ |
Cell adhesion molecules (CAMs) | Cell adhesion (GO:0007155) | ↓ | ↓ |
Cell communication | Cell adhesion (GO:0007155) | ↓ | ↓ |
Complement and coagulation cascade | Complement activation (GO:0006956) | ↓ | N/A |
ECM-receptor interaction | Cell adhesion (GO:0007155) | ↓ | ↓ |
Focal Adhesion | Cell adhesion (GO:0007155) | ↓ | ↓ |
Phenylalanine metabolism | Phenol metabolism (GO:0018958) | ↓ | N/A |