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Table 4 Comparison of results obtained from this study with those based on Gene Ontology Processes by Sandberg et al. [7]

From: Pathway-specific differences between tumor cell lines and normal and tumor tissue cells

KEGG Pathway Related GO category Direction of regulation in cell lines with respect to tumors
   This study Gene Ontology Study [7]
ATP synthesis ATP synthesis coupled proton transport (GO:0015986)
Cell cycle Cell cycle (GO:0007049)
One carbon pool by folate Nucleotide biosynthesis (GO:0009165)
Oxidative phosphorylation Oxidative phosphorylation (GO:0006119)
Proteasome Ubiquitin-dependent protein catabolism (GO:0006511); Modification-dependent protein catabolism (GO:0019941)
Purine metabolism Purine nucleotide metabolism (GO:0006163)
Pyrimidine metabolism Nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0006139)
Ribosome Protein biosynthesis (GO:0006412)
RNA polymerase Nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0006139)
Cell adhesion molecules (CAMs) Cell adhesion (GO:0007155)
Cell communication Cell adhesion (GO:0007155)
Complement and coagulation cascade Complement activation (GO:0006956) N/A
ECM-receptor interaction Cell adhesion (GO:0007155)
Focal Adhesion Cell adhesion (GO:0007155)
Phenylalanine metabolism Phenol metabolism (GO:0018958) N/A
  1. The symbol [↑] indicates upregulation in cell lines with respect to tumors and [↓] indicates downregulation in cell lines with respect to tumors (CL - T).