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Table 1 RCC tumor-associated angiogenesis (Factor VIII-related antigen), proliferation (PCNA), and apoptosis (TUNEL) in SCID mice treated with anti-CXCL12

From: Stromal Derived Factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasis

Group

FVIIIRAA+/hpf

PCNA+/hpf

TUNEL+/hpf

VC CTRL

9.3 ± 1.3

40.4 ± 6.6

9.2 ± 1.1

VC αCXCL12

6.6 ± 0.8

44.7 ± 3.1

6.7 ± 1.0

 

p = 0.19

p = 0.60

p = 0.15

KD CTRL

26.7 ± 1.4

107.5 ± 4.8

28.9 ± 2.5

KD αCXCL12

30.1 ± 1.8

116.6 ± 7.6

23.4 ± 3.0

 

p = 0.13

p = 0.29

p = 0.17

  1. Factor VIII-related antigen stained vessels or PCNA or TUNEL stained cells were counted in 5–10 high power fields (hpf; ×400) in three sections from each group. A FVIIIRA: Factor VIII-related antigen. CTRL = control serum. αCXCL12 = specific neutralizing anti-CXCL12 serum.
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Molecular Cancer

ISSN: 1476-4598