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Table 1 RCC tumor-associated angiogenesis (Factor VIII-related antigen), proliferation (PCNA), and apoptosis (TUNEL) in SCID mice treated with anti-CXCL12

From: Stromal Derived Factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasis

Group FVIIIRAA+/hpf PCNA+/hpf TUNEL+/hpf
VC CTRL 9.3 ± 1.3 40.4 ± 6.6 9.2 ± 1.1
VC αCXCL12 6.6 ± 0.8 44.7 ± 3.1 6.7 ± 1.0
  p = 0.19 p = 0.60 p = 0.15
KD CTRL 26.7 ± 1.4 107.5 ± 4.8 28.9 ± 2.5
KD αCXCL12 30.1 ± 1.8 116.6 ± 7.6 23.4 ± 3.0
  p = 0.13 p = 0.29 p = 0.17
  1. Factor VIII-related antigen stained vessels or PCNA or TUNEL stained cells were counted in 5–10 high power fields (hpf; ×400) in three sections from each group. A FVIIIRA: Factor VIII-related antigen. CTRL = control serum. αCXCL12 = specific neutralizing anti-CXCL12 serum.